{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:26:00Z","timestamp":1790270760534,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC98\u20102314\u2010B\u2010038\u2010020\u2010MY3"],"award-info":[{"award-number":["NSC98\u20102314\u2010B\u2010038\u2010020\u2010MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We attempted to determine risk factors, particularly pathophysiological changes, for early cardiovascular mortality in bipolar disorder (BD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 5416 inpatients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD; ICD 9: 401\u2013443) before the age of 65\u2009years were identified. Two living BD patients and two mentally healthy adults were matched with each deceased patient as control subjects according to age (\u00b12\u2009years), sex, and date (\u00b13\u2009years) of the final\/index admission or the date of general health screening. Data were obtained through medical record reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty percent of CVD deaths occurred within 10\u2009years following the index admission. Conditional logistic regression revealed that the variables most strongly associated with CVD mortality were the leukocyte count and heart rate on the first day of the index hospitalization, as the deceased BD patients were compared with the living BD controls. Systolic pressure on the first day of the index hospitalization can be substituted for heart rate as another risk factor for CVD mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is suggested that systemic inflammation and sympathetic overactivity during the acute phase of BD may be risk factors for early CVD mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12538","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T02:57:00Z","timestamp":1495162620000},"page":"716-724","source":"Crossref","is-referenced-by-count":21,"title":["Risk factors for early cardiovascular mortality in patients with bipolar disorder"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-0055","authenticated-orcid":false,"given":"Shang\u2010Ying","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hsien","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Health Business Administration Meiho University  Pingtung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao\u2010Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Hsuan","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou\u2010Hung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chian\u2010Jue","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Taipei City Psychiatric Center Taipei City Hospital, Songde Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital and Social Welfare Organizations Administration Commission Ministry of Health and Welfare  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002373"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.9.844"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v66n1215"},{"key":"e_1_2_8_5_1","first-page":"40","article-title":"Cardiovascular morbidity and mortality in bipolar disorder","volume":"23","author":"Weiner M","year":"2011","journal-title":"Ann. 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