{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:14:15Z","timestamp":1769177655162,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["JP15K09866"],"award-info":[{"award-number":["JP15K09866"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Impaired social functioning is a common characteristic of patients with schizophrenia. Social functioning requires the complex operation of various executive functions. Deficits in the prefrontal cortex (PFC) have been implicated in executive dysfunction. Here we aimed to clarify the relation between subjectively and objectively assessed social functioning, and their associations with PFC function in patients with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three patients and 22 age\u2010 and sex\u2010matched healthy controls (HC) were assessed. In the schizophrenia group, self\u2010 and caregiver\u2010rated social functioning were measured using the Specific Level of Functioning Assessment (SLOF). The hemodynamic responses elicited by a verbal fluency task (VFT) in three regions of interest in the frontotemporal area were measured using multi\u2010channel near\u2010infrared spectroscopy (NIRS). We also investigated psychiatric symptoms, neurocognition, and cognitive insight to assess possible confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant positive correlations were found between self\u2010 and caregiver\u2010rated SLOF composite scores and three subdomain scores. Self\u2010 and caregiver\u2010rated SLOF composite scores were significantly associated with dorsolateral PFC and frontopolar cortex (DLPFC\/FPC) activation during the VFT. Psychiatric symptoms, global functioning, neurocognition, and cognitive insight were not associated with NIRS signals. General psychopathology was associated with NIRS signals in the ventrolateral PFC and the anterior temporal cortex. DLPFC and FPC activity may be associated with social functioning in patients with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the two distinct assessments of social functioning were significantly correlated. Moreover, DLPFC and FPC function was strongly associated with social functioning and the ability to carry out daily life in patients with schizophrenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12548","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T13:12:40Z","timestamp":1498655560000},"page":"769-779","source":"Crossref","is-referenced-by-count":21,"title":["Association between social functioning and prefrontal cortex function during a verbal fluency task in schizophrenia: <scp>A<\/scp> near\u2010infrared spectroscopic study"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6026-8178","authenticated-orcid":false,"given":"Masashi","family":"Itakura","sequence":"first","affiliation":[{"name":"Division of Psychiatry, Department of Brain and Neuroscience Tottori University Faculty of Medicine  Yonago Japan"},{"name":"Department of Psychiatry Shimane Prefectural Psychiatric Medical Center  Izumo 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