{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:54:05Z","timestamp":1789912445767,"version":"4.0.1"},"reference-count":109,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T00:00:00Z","timestamp":1551312000000},"content-version":"am","delay-in-days":324,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009028","name":"Research Institute of Science and Technology for Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Aim<\/jats:title>CX3CR1<\/jats:italic>, a G\u2010protein\u2010coupled receptor, is involved in various inflammatory processes. Two non\u2010synonymous single nucleotide polymorphisms, V249I (rs3732379) and T280M (rs3732378), are located in the sixth and seventh transmembrane domains of the CX3CR1 protein, respectively. Previous studies have indicated significant associations between T280M and leukocyte functional characteristics, including adhesion, signaling, and chemotaxis, while the function of V249I is unclear. In the brain, microglia are the only proven and widely accepted CX3CR1\u2010expressing cells. This study aimed to specify whether there were specific brain regions on which these two single nucleotide polymorphisms exert their biological impacts through their functional effects on microglia.<\/jats:p><\/jats:sec>Methods<\/jats:title>Associations between the single nucleotide polymorphisms and brain characteristics, including gray and white matter volumes, white matter integrity, resting arterial blood volume, and cerebral blood flow, were evaluated among 1300 healthy Japanese individuals.<\/jats:p><\/jats:sec>Results<\/jats:title>The major allele carriers (V249 and T280) were significantly associated with an increased total arterial blood volume of the whole brain, especially around the bilateral precuneus, left posterior cingulate cortex, and left posterior parietal cortex. There were no significant associations between the genotypes and other brain structural indicators.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This finding suggests that the CX3CR1<\/jats:italic> variants may affect arterial structures in the brain, possibly via interactions between microglia and brain microvascular endothelial cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12649","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T10:34:45Z","timestamp":1519727685000},"page":"409-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain"],"prefix":"10.1111","volume":"72","author":[{"given":"Mai","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Disaster Psychiatry, International Research Institute of Disaster Science Tohoku University Sendai 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