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Antidepressants (AD), including selective serotonin reuptake inhibitors (SSRI), function by gradually improving information processing within these networks. AD have been shown to induce a state of juvenile\u2010like plasticity comparable to that observed during developmental critical periods: Such critical\u2010period\u2010like plasticity allows brain networks to better adapt to extrinsic and intrinsic signals. We have coined this drug\u2010induced state of juvenile\u2010like plasticity \u2018iPlasticity.\u2019 A combination of iPlasticity induced by chronic SSRI treatment together with training, rehabilitation, or psychotherapy improves symptoms of neuropsychiatric disorders and issues underlying the developmentally or genetically malfunctioning networks. We have proposed that iPlasticity might be a critical component of AD action. We have demonstrated that iPlasticity occurs in the visual cortex, fear erasure network, extinction of aggression caused by social isolation, and spatial reversal memory in rodent models. Chronic SSRI treatment is known to promote neurogenesis and to cause dematuration of granule cells in the dentate gyrus and of interneurons, especially parvalbumin interneurons enwrapped by perineuronal nets in the prefrontal cortex, visual cortex, and amygdala. Brain\u2010derived neurotrophic factor (BDNF), via its receptor tropomyosin kinase receptor B, is involved in the processes of synaptic plasticity, including neurogenesis, neuronal differentiation, weight of synapses, and gene regulation of synaptic formation. BDNF can be activated by both chronic SSRI treatment and neuronal activity. Accordingly, the BDNF\/tropomyosin kinase receptor B pathway is critical for iPlasticity, but further analyses will be needed to provide mechanical insight into the processes of iPlasticity.<\/jats:p>","DOI":"10.1111\/pcn.12683","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T09:50:15Z","timestamp":1527328215000},"page":"633-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["iPlasticity: Induced juvenile\u2010like plasticity in the adult brain as a mechanism of antidepressants"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-7362","authenticated-orcid":false,"given":"Juzoh","family":"Umemori","sequence":"first","affiliation":[{"name":"Neuroscience Center, HiLIFE University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Winkel","sequence":"additional","affiliation":[{"name":"Neuroscience Center, HiLIFE University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Didio","sequence":"additional","affiliation":[{"name":"Neuroscience Center, HiLIFE University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Llach Pou","sequence":"additional","affiliation":[{"name":"Neuroscience Center, HiLIFE University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Neuroscience Center, HiLIFE University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0038550"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830190015002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1629"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1133"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1218"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1162\/0898929042304796"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00047-1"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144327"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007079"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.05.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1977.0050"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1346729"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80102-6"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1937"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.02.014"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2012"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1899"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.12.010"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70314-8"},{"key":"e_1_2_12_22_1","first-page":"33","article-title":"Clomipramine (Anafranil) and behaviour therapy in obsessive\u2010compulsive and phobic disorders","volume":"5","author":"Amin MM","year":"1977","journal-title":"J. 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