{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:27:55Z","timestamp":1768274875802,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medicine Interdisciplinary Seed Fund","award":["BMU20140435"],"award-info":[{"award-number":["BMU20140435"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to compare alterations in serum bioenergetic markers within a well\u2010characterized sample of adults with schizophrenia at baseline and after 8 weeks of pharmacological treatment with the hypothesis that treatment would be associated with significant changes in bioenergetic markers given the role of bioenergetic dysfunction in schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited adults with schizophrenia (<jats:italic>n<\/jats:italic> = 122) who had not received pharmacological treatment for at least 1 month prior to enrollment, including drug\u2010na\u00efve (i.e., first\u2010episode) participants and treatment non\u2010adherent participants. Pre\u2010 and post\u2010treatment serum samples were analyzed using liquid chromatography\u2013tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metabolites with the greatest change, when comparing pre\u2010 and post\u2010treatment levels, were identified revealing 14 water\u2010soluble metabolites of interest. The composition of these metabolites was: amino acids (<jats:italic>n<\/jats:italic> = 6), carnitines (<jats:italic>n<\/jats:italic> = 4), polar lipids (<jats:italic>n<\/jats:italic> = 3), and organic acid (<jats:italic>n<\/jats:italic> = 1). All amino acids and lysophosphatidylcholines (LysoPC) were increased, while the four carnitines \u2013 oleoylcarnitine, L\u2010palmitoylcarnitine, linoleyl carnitine, and L\u2010acetylcarnitine \u2013 were decreased post\u2010treatment. Of these metabolite biomarkers, six \u2013 oleoylcarnitine, linoleyl carnitine, L\u2010acetylcarnitine, LysoPC(15:0), D\u2010glutamic acid, and L\u2010arginine \u2013 were identified as having most consistently and predictably changed after 8 weeks of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study identified several bioenergetic markers that consistently change with pharmacological treatment. These bioenergetic changes may provide further insights into the pathophysiology of schizophrenia along with furthering our understanding of the mechanisms subserving both the effects (e.g., antipsychotic effects) and side\u2010effects (e.g., metabolic syndrome) of antipsychotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12779","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T06:42:41Z","timestamp":1535611361000},"page":"100-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Serum metabolic profiling using small molecular water\u2010soluble metabolites in individuals with schizophrenia: A longitudinal study using a pre\u2013post\u2010treatment design"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-2676","authenticated-orcid":false,"given":"Bing","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Laboratorial 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