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To replicate previous findings, including those for smaller CNV (&gt;10kb), the PRS between SCZ patients with and without CNV were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array\u2010based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and without \u2018clinically significant\u2019 CNV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First, we replicated the higher PRS in patients with SCZ compared to that in HC (without taking into account the CNV). For clinically significant CNV, as defined by the American College of Medical Genetics (\u2018pathogenic\u2019 and \u2018uncertain clinical significance, likely pathogenic\u2019 CNV), 66 patients with SCZ carried clinically significant CNV, whereas 658 SCZ patients had no such CNV. In the comparison of PRS between cases with\/without the CNV, despite no significant difference in PRS, significant enrichment of the well\u2010established risk CNV (22q11.2 deletion and 47,XXY\/47,XXX) was observed in the lowest decile of PRS in SCZ patients with the CNV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the present study failed to replicate the significant difference in PRS between SCZ patients with and without clinically significant CNV, SCZ patients with well\u2010established risk CNV tended to have a lower PRS. Therefore, we speculate that the CNV in SCZ patients with lower PRS may contain \u2018genuine\u2019 risk; PRS is a possible tool for prioritizing clinically significant CNV because the power of the CNV association analysis is limited due to their rarity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12926","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T22:01:08Z","timestamp":1567029668000},"page":"35-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Polygenic risk scores in schizophrenia with clinically significant copy number variants"],"prefix":"10.1111","volume":"74","author":[{"given":"Satoru","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake 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