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A common single nucleotide polymorphism (SNP), <jats:italic>GFAP<\/jats:italic> \u2013250 C\/A (rs2070935), is associated with the transcriptional regulation of GFAP, which can potentially result in the genotype\u2010specific brain structure. This study aimed to verify the biological effects of the <jats:italic>GFAP<\/jats:italic> variants on brain structure and function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the associations between the <jats:italic>GFAP<\/jats:italic> variants and magnetic resonance imaging findings, including gray and white matter volumes, white matter integrity, and resting arterial blood flow, from 1212 healthy Japanese subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>GFAP<\/jats:italic> \u2013250 C\/A genotype was significantly associated with total gray matter volume, total white matter volume, average mean diffusivity, and mean cerebral blood flow. In voxel\u2010by\u2010voxel analyses, the <jats:italic>GFAP<\/jats:italic> genotype showed significant associations with the regional gray and white matter volumes in the inferior frontal lobe and corpus callosum, the regional mean diffusivity in the left posterior region, and the regional cerebral blood flow throughout the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed a common SNP that is significantly associated with multiple global brain structure parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12932","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T15:19:34Z","timestamp":1568128774000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A single nucleotide polymorphism (\u2212250 A\/C) of the <i>GFAP<\/i> gene is associated with brain structures and cerebral blood 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