{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:03:10Z","timestamp":1793833390014,"version":"4.6.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011259","name":"FP7 International Cooperation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003808","name":"Hospital Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Acupuncture has benefits in the rehabilitation of neuropsychiatric sequelae of stroke. This study was aimed to evaluate the effectiveness of dense cranial electroacupuncture stimulation plus body acupuncture (DCEAS+BA) in treating poststroke depression (PSD), functional disability, and cognitive deterioration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this assessor\u2010 and participant\u2010blinded, randomized controlled trial, 91 stroke patients who initially had PSD were randomly assigned to either DCEAS+BA (<jats:italic>n<\/jats:italic> =\u200945) or minimum acupuncture stimulation as controls (<jats:italic>n<\/jats:italic> =\u200946) for three sessions per week over 8 consecutive weeks. The primary outcome was baseline\u2010to\u2010end\u2010point change in score of the 17\u2010item Hamilton Depression Rating Scale. Secondary outcomes included the Montgomery\u2013\u00c5sberg Depression Rating Scale for depressive symptoms, the Barthel Index for functional disability, and the Montreal Cognitive Assessment for cognitive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DCEAS+BA\u2010treated patients showed strikingly greater end\u2010point reduction than MAS\u2010treated patients in scores of the three symptom domains. The clinical response rate, defined as an at least 50% baseline\u2010to\u2010end\u2010point reduction in 17\u2010item Hamilton Depression Rating Scale score, was markedly higher in the DCEAS+BA\u2010treated group than that of controls (40.0% vs 17.4%, <jats:italic>P<\/jats:italic> = 0.031). Incidence of adverse events was not different in the two groups. Subgroup analysis revealed that DCEAS+BA with electrical stimulation on forehead acupoints was more apparent in reducing Barthel\u2010Index\u2010measured disability than that without electrical stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DCEAS+BA, particularly with electrical stimulation on forehead acupoints, reduces PSD, functional disability, and cognitive deterioration of stroke patients. It can serve as an effective rehabilitation therapy for neuropsychiatric sequelae of stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12959","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T15:04:10Z","timestamp":1574262250000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Assessor\u2010 and participant\u2010blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-3426","authenticated-orcid":false,"given":"Zhang\u2010Jin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chinese Medicine University of Hong Kong  Hong Kong 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