{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:08:08Z","timestamp":1780117688412,"version":"3.54.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The primary objective of this study was to examine the effectiveness of mindfulness\u2010based cognitive therapy (MBCT) in secondary\u2010care settings where the vast majority of the patients have already undergone pharmacotherapy but have not remitted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible participants were aged between 20 and 75\u2009years and met the criteria for panic disorder\/agoraphobia or social anxiety disorder specified in the DSM\u2010IV. They were randomly assigned to either the MBCT group (<jats:italic>n<\/jats:italic> = 20) or the wait\u2010list control group (<jats:italic>n<\/jats:italic> = 20). The primary outcome was the difference in mean change scores between pre\u2010 and post\u2010intervention assessments on the State\u2013Trait Anxiety Inventory (STAI). The outcome was analyzed using an intent\u2010to\u2010treat approach and a mixed\u2010effect model repeated measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed significant differences in mean change scores for the STAI State Anxiety subscale (difference,\u2009\u221210.1; 95% confidence interval,\u2009\u221216.9 to \u22123.2; <jats:italic>P<\/jats:italic> &lt;\u20090.005) and STAI Trait Anxiety subscale (difference,\u2009\u221211.7; 95% confidence interval,\u2009\u221217.0 to \u22126.4; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) between the MBCT and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MBCT is effective in patients with anxiety disorders in secondary\u2010care settings where the vast majority of patients are treatment\u2010resistant to pharmacotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.12960","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T15:45:38Z","timestamp":1574869538000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effectiveness of mindfulness\u2010based cognitive therapy in patients with anxiety disorders in secondary\u2010care settings: A randomized controlled trial"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-6341","authenticated-orcid":false,"given":"Akira","family":"Ninomiya","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Center for Stress Research Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2626-8123","authenticated-orcid":false,"given":"Mitsuhiro","family":"Sado","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Center for Stress Research Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunre","family":"Park","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Medicine Care Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Division of Patient Safety Keio University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-6844","authenticated-orcid":false,"given":"Teppei","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Clinical and Translational Research Center Keio University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joichiro","family":"Shirahase","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Center for Stress Research Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"},{"name":"Center for Stress Research Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"14","article-title":"Social anxiety disorder clinical course and outcome: Review of Harvard\/Brown Anxiety Research Project (HARP) findings","volume":"67","author":"Keller MB","year":"2006","journal-title":"J. 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