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Genes associated with a risk of developing AD were selected as candidate genes. NPS were assessed using the Neuropsychiatric Inventory Questionnaire (NPI\u2010Q), and the NPI\u2010Q total score and sub\u2010scores for the Psychosis, Mood, and Frontal Syndrome domains were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AD and the <jats:italic>APOE<\/jats:italic> \u03b54 allele exhibited more obvious symptoms of psychosis. Mood symptoms were associated with <jats:italic>CD33<\/jats:italic> rs3865444 and <jats:italic>EPHA1<\/jats:italic> rs11767557, and frontal symptoms were associated with <jats:italic>SORL1<\/jats:italic> rs3824968. A 1\u2010year Time\u2009\u00d7\u2009Alleles interaction effect of <jats:italic>CD33<\/jats:italic> rs3865444 on mood symptoms was discerned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Risk genes of AD, which are also associated with NPS, are <jats:italic>APOE<\/jats:italic> \u03b54 for psychosis, <jats:italic>CD33<\/jats:italic> and <jats:italic>EPHA1<\/jats:italic> for mood symptoms, and <jats:italic>SORL1<\/jats:italic> for frontal symptoms. The association between <jats:italic>CD33<\/jats:italic> and mood symptoms is dynamic and could change over 1\u2009year; however, the results should be interpreted with caution because corrections for multiple comparisons were not performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13150","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T21:59:44Z","timestamp":1601330384000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetics of neuropsychiatric symptoms in patients with Alzheimer's disease: A <scp>1\u2010year follow\u2010up<\/scp> study"],"prefix":"10.1111","volume":"74","author":[{"given":"Mei\u2010Feng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Psychiatry, School of Medicine and Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Neurological Institute, Dementia and Parkinson's Disease Integrated Center, and Center for Geriatrics and Gerontology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Faculty of Medicine, Institute of Clinical Medicine National Yang\u2010Ming University Schools of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Psychiatry, School of Medicine and Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chu","family":"Liao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University Schools of Medicine  Taipei Taiwan"},{"name":"Department of Neurology Neurological Institute, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuu\u2010Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University Schools of Medicine  Taipei Taiwan"},{"name":"Department of Neurology Neurological Institute, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsin","family":"Yang","sequence":"additional","affiliation":[{"name":"National Institute of Cancer Research National Health Research Institutes  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-8834","authenticated-orcid":false,"given":"Cheng\u2010Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"Department of Psychiatry, School of Medicine and Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3351","authenticated-orcid":false,"given":"Jong\u2010Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University Schools of Medicine  Taipei Taiwan"},{"name":"Department of Neurology Neurological Institute, Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"3","article-title":"Behavioral and psychological symptoms of dementia: A current focus for clinicians, researchers, and caregivers","volume":"62","author":"Finkel SI","year":"2001","journal-title":"J. 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