{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:02:30Z","timestamp":1759384950442,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dm0107093","JP18dm0207012","JP18dm0307002"],"award-info":[{"award-number":["JP18dm0107093","JP18dm0207012","JP18dm0307002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012389","name":"National Institute of Information and Communications Technology","doi-asserted-by":"publisher","award":["1870110"],"award-info":[{"award-number":["1870110"]}],"id":[{"id":"10.13039\/501100012389","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Several studies have reported altered age\u2010associated changes in white matter integrity in bipolar disorder (BD). However, little is known as to whether these age\u2010related changes are illness\u2010specific. We assessed disease\u2010specific effects by controlling for age and investigated age\u2010associated changes and Group\u2009\u00d7\u2009Age interactions in white matter integrity among major depressive disorder (MDD) patients, BD patients, and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy controls (<jats:italic>n<\/jats:italic> = 96; age range, 20\u201377 years), MDD patients (<jats:italic>n<\/jats:italic> = 101; age range, 25\u201378 years), and BD patients (<jats:italic>n<\/jats:italic> = 58; age range, 22\u201376\u2009years) participated in this study. Fractional anisotropy (FA) derived from diffusion tensor imaging in 54 white matter tracts were compared after controlling for the linear and quadratic effect of age using a generalized linear model. Age\u2010related effects and Age\u2009\u00d7\u2009Group interactions were also assessed in the model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main effect of group was significant in the left column and body of the fornix after controlling for both linear and quadratic effects of age, and in the left body of the corpus callosum after controlling for the quadratic effect of age. BD patients exhibited significantly lower FA relative to other groups. There was no Age\u2009\u00d7\u2009Group interaction in the tracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant FA reductions were found in BD patients after controlling for age, indicating that abnormal white matter integrity in BD may occur at a younger age rather than developing progressively with age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13166","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T16:51:28Z","timestamp":1603385488000},"page":"46-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age\u2010related white matter changes revealed by a whole\u2010brain fiber\u2010tracking method in bipolar disorder compared to major depressive disorder and healthy controls"],"prefix":"10.1111","volume":"75","author":[{"given":"Yoshikazu","family":"Masuda","sequence":"first","affiliation":[{"name":"Department of Psychiatry and 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