{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:33:53Z","timestamp":1778999633079,"version":"3.51.4"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012120","name":"Ontario Mental Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The N400 event\u2010related brain potential (ERP) semantic priming effect is thought to reflect activation by meaningful stimuli of related concepts in semantic memory and has been found to be deficient in schizophrenia. We tested the hypothesis that, among individuals at clinical high risk (CHR) for psychosis, N400 semantic priming deficits predict worse symptomatic and functional outcomes after one year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured N400 semantic priming at baseline in CHR patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a047) and healthy control participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) who viewed prime words each followed by a related or unrelated target word, at stimulus\u2010onset asynchronies (SOAs) of 300 or 750 ms. We measured patients' psychosis\u2010like symptoms with the Scale of Prodromal Symptoms (SOPS) Positive subscale, and academic\/occupational and social functioning with the Global Functioning (GF):Role and Social scales, respectively, at baseline and one\u2010year follow\u2010up (<jats:italic>n<\/jats:italic>\u00a0=\u00a029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CHR patients exhibited less N400 semantic priming than controls across SOAs; planned contrasts indicated this difference was significant at the 750\u2010ms but not the 300\u2010ms SOA. In patients, reduced N400 semantic priming at the 750\u2010ms SOA was associated with lower GF:Social scores at follow\u2010up, and greater GF:Social decrements from baseline to follow\u2010up. Patients' N400 semantic priming was not associated with SOPS Positive or GF:Role scores at follow\u2010up, or change in these from baseline to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In CHR patients, reduced N400 semantic priming at baseline predicted worse social functioning after one year, and greater decline in social functioning over this period. Thus, the N400 may be a useful prognostic biomarker of real\u2010world functional outcome in CHR patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13330","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:02:42Z","timestamp":1642410162000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>N400<\/scp> event\u2010related brain potential and functional outcome in persons at clinical high risk for psychosis: A longitudinal study"],"prefix":"10.1111","volume":"76","author":[{"given":"Jennifer R.","family":"Lepock","sequence":"first","affiliation":[{"name":"Institute of Medical Science, University of Toronto  Toronto Ontario Canada"},{"name":"Centre for Addiction and Mental Health  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory J.","family":"Gerritsen","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Graduate Department of Psychological Clinical Science University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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