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While schizophrenia patients show abnormal oscillatory responses across multiple frequencies at rest, it is unclear whether the functional relationships among frequency bands are intact. This study aimed to characterize the lower frequency (delta\/theta, 1\u20138 Hz) phase and the amplitude of gamma oscillations in healthy subjects and schizophrenia patients at rest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Low frequency\u2010phase (delta\u2010 and theta\u2010 band) angles and gamma\u2010band amplitude relationships were assessed in 142 schizophrenia patients and 128 healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant low\u2010frequency phase alteration related to high\u2010power gamma was detected across broadly distributed scalp regions in both healthy subjects and patients. In patients, delta phase synchronization related to high\u2010power gamma was significantly decreased at the frontocentral, right middle temporal, and left temporoparietal electrodes but significantly increased at the left parietal electrode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010power gamma\u2010related delta phase alteration may reflect a core pathophysiologic abnormality in schizophrenia. Data\u2010driven measures of functional relationships among frequency bands may prove useful in the development of novel therapeutics. Future studies are needed to determine whether these alterations are specific to schizophrenia or appear in other neuropsychiatric patient populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13331","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:03:04Z","timestamp":1642410184000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["High\u2010power gamma\u2010related delta phase alteration in schizophrenia patients at rest"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-0981","authenticated-orcid":false,"given":"Daisuke","family":"Koshiyama","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California San Diego  La Jolla California 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