{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:11:59Z","timestamp":1792026719626,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21dk0307103"],"award-info":[{"award-number":["JP21dk0307103"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Medications for the treatment of bipolar disorder (BD) could affect patients' cognitive function. Patients with BD present with neurocognitive impairment even in a remission state. Little research is available on the daily functioning, especially driving performance, of stable outpatients with BD under pharmacological treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 58 euthymic outpatients with BD undergoing real\u2010world pharmacotherapy and 80 sex\u2010 and age\u2010matched healthy controls (HCs) were enrolled. Three driving tasks using a driving simulator\u2014road\u2010tracking, car\u2010following, and harsh\u2010braking\u2014and three cognitive tasks\u2014Continuous Performance Test, Wisconsin Card Sorting Test, and Trail\u2010Making Test\u2014were evaluated. Symptom assessment scales\u2014Young Mania Rating Scale, Structured Interview Guide for the Hamilton Depression Rating Scale, Beck Depression Inventory\u2010II, Social Adaptation Self\u2010evaluation Scale, and Stanford Sleepiness Scale\u2014were also completed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Car\u2010following and road\u2010tracking performance were significantly impaired in patients with BD compared with HCs after adjusting for demographic variables, but these performances generally overlapped. Broad neurocognitive functions were significantly lower in the patients with BD compared to HCs, but car\u2010following performance was significantly negatively correlated with sustained attention only. Although most patients received multiple medications rather than monotherapy, no relationship between prescriptions and driving performance was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Euthymic patients with BD under steady\u2010state pharmacotherapy had impaired driving performance compared with HCs, but the overlapping distributions of driving performance suggested that driving performance is not always deteriorated in patients with BD. Therefore, attentional function may be a useful clinical feature for judging driving aptitude in patients with BD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13332","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:06:39Z","timestamp":1642410399000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Driving performance of euthymic outpatients with bipolar disorder undergoing real\u2010world pharmacotherapy"],"prefix":"10.1111","volume":"76","author":[{"given":"Akiko","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-3372","authenticated-orcid":false,"given":"Kunihiro","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Okehazama Hospital  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonori","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Sapporo Ekimae Clinic  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Medical Care Toranomon  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-4898","authenticated-orcid":false,"given":"Norio","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nagoya University, Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.3.246"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(01)00242-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.1.41"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.08.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291703001570"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852918001463"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01011.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.02.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08r04972"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01910.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1814-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.126.6.807"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2466\/PR0.67.6.483-489"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196512232732605"},{"key":"e_1_2_10_16_1","volume-title":"Drug Use and Road Safety: A Policy Brief","author":"World Health Organization","year":"2016"},{"key":"e_1_2_10_17_1","volume-title":"Evaluating Drug Effects on the Ability to Operate a Motor Vehicle Guidance for Industry","author":"US Food and Drug Administration","year":"2017"},{"key":"e_1_2_10_18_1","volume-title":"Assessing fitness to drive: guide for medical professionals","author":"Driver and Vehicle Licensing Agency","year":"2021"},{"key":"e_1_2_10_19_1","unstructured":"Assessing Fitness to Drive.2016. 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