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Based on that guideline, the present guideline was developed and revised to incorporate the suggestions of global experts and the latest published evidence. In the diagnosis of late\u2010life depression, it is important to carefully differentiate it from bipolar disorders, depressive states caused by physical and organic brain disease, drug effects, and dementia, and to determine the comorbidity between late\u2010life depression and dementia. It is necessary to fully understand the clinical characteristics and psychosocial background of late\u2010life depression, evaluate the patient's condition, and provide basic interventions based on these factors. Problem\u2010solving therapy, reminiscence therapy\/life review therapy, and behavioral activation therapy, and other forms of psychotherapy can reduce depressive symptoms. In terms of pharmacotherapy, newer antidepressants or non\u2010tricyclic antidepressants are recommended for late\u2010life depression, and it is recommended that the efficacy of least the minimal effective dosage should first be determined. Switching antidepressants and aripiprazole augmentation can be used to treatment\u2010resistant therapy. Electroconvulsive therapy and repetitive transcranial magnetic stimulation have demonstrated usefulness for late\u2010life depression. Exercise therapy, high\u2010intensity light therapy, and diet therapy also show some effectiveness and are useful for late\u2010life depression. Continuation therapy should be maintained for at least 1\u00a0year after remission.<\/jats:p>","DOI":"10.1111\/pcn.13349","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T10:29:44Z","timestamp":1646994584000},"page":"222-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Guidelines for diagnosis and treatment of depression in older adults: A report from the Japanese Society of mood disorders"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-8776","authenticated-orcid":false,"given":"Hajime","family":"Baba","sequence":"first","affiliation":[{"name":"Department of Psychiatry Juntendo University Koshigaya Hospital  Saitama Japan"},{"name":"Department of Psychiatry &amp; Behavioral Science Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-1054","authenticated-orcid":false,"given":"Shinsuke","family":"Kito","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National Center Hospital, National Center of Neurology and Psychiatry  Tokyo Japan"},{"name":"Department of Psychiatry Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-6769","authenticated-orcid":false,"given":"Kazutaka","family":"Nukariya","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Jikei University School of Medicine  Tokyo Japan"},{"name":"Department of Psychiatry Jikei University School of Medicine, Kashiwa Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1862-7998","authenticated-orcid":false,"given":"Minoru","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Meishin\u2010kai Shibata Hospital  Toyama Japan"},{"name":"Department of Psychiatry Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-7124","authenticated-orcid":false,"given":"Noboru","family":"Fujise","sequence":"additional","affiliation":[{"name":"Health Care Center, Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3096","authenticated-orcid":false,"given":"Junichi","family":"Iga","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Ehime University Graduate School of Medicine  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Oshibuchi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tokyo Women's Medical University  Tokyo Japan"},{"name":"Department of Child Psychiatry Kanagawa Children's Medical Center  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Miyakonojo Shinsei Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-5870","authenticated-orcid":false,"given":"Mahiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Nippon Medical School, Chiba Hokusoh Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Graduate School of Comprehensive Human Sciences University of Tsukuba  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-5273","authenticated-orcid":false,"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood Disorders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"A committee for treatment guidelines of mood disorders of the Japanese Society of Mood Disorders.Guidelines for Treatment of Depression. 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