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Our objective was to examine whether longitudinal changes in clinical symptoms are associated with quality of life in ultra\u2010high risk individuals and patients with recent\u2010onset psychotic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals with ultra\u2010high risk and patients with recent\u2010onset psychosis disorder were recruited in the same clinical settings at baseline and were followed up with more than 6\u2009months and less than 5\u2009years later. We assessed five factors of clinical symptoms using the positive and negative syndrome scale, and quality of life using the World Health Organization quality of life questionnaire\u2010short form. We used multiple regression to examine the relationships between clinical symptoms and quality of life while controlling for diagnosis, follow\u2010up period, age, and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected from 22 individuals with ultra\u2010high risk and 27 patients with recent\u2010onset psychosis disorder. The multiple regression analysis results indicated that the more severe anxiety\/depression was at baseline, the poorer the quality of life at follow\u2010up. Further, improvement of anxiety\/depression and disorganized thoughts were associated with improvement in quality of life. The difference in diagnosis did not affect the association between clinical symptoms and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that the improvement of anxiety\/depression and disorganized thoughts is important in the early stages of psychosis before it becomes severe, affecting the quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13359","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T02:38:37Z","timestamp":1648607917000},"page":"552-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The association between clinical symptoms and later subjective quality of life in individuals with ultra\u2010high risk for psychosis and recent\u2010onset psychotic disorder: A longitudinal 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