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Panic disorder (PD) is considered to be a fear network disorder along with prefrontal activity alterations. We aim to assess the effect of tDCS on clinical and physiological parameters in PD for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this triple\u2010blind randomized sham\u2010controlled pilot study, 30 individuals with PD were allocated into active and sham groups to receive 10 sessions of tDCS targeting the dorsolateral prefrontal cortex bilaterally at 2\u2009mA for 20\u2010min duration over 2\u2009weeks. The clinical severity, threat\u2010related attentional bias, interoceptive accuracy, and emotional recognition were assessed before, immediately after, and 1\u2009month after tDCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Active tDCS, in comparison to sham, did not elicit more favorable clinical and neuropsychological\/physiological outcomes in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study provides the first clinical and neurobehavioral results of prefrontal tDCS in PD and indicates that prefrontal tDCS was not superior to sham in PD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13378","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T17:48:02Z","timestamp":1652982482000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Transcranial direct current stimulation does not improve 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