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These intergenerational effects are observed in patients with mood disorders, with a particularly strong association of depression between mothers and daughters. The main purpose of our study was to investigate female\u2010specific intergenerational transmission patterns in the human brain among patients with depression and their never\u2010depressed offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 78 participants from 34 families, which included remitted parents with a history of depression and their never\u2010depressed biological offspring. We used source\u2010based and surface\u2010based morphometry analyses of magnetic resonance imaging data to examine the degree of associations in brain structure between four types of parent\u2010offspring dyads (i.e. mother\u2010daughter, mother\u2010son, father\u2010daughter, and father\u2010son).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using independent component analysis, we found a significant positive correlation of gray matter structure between exclusively the mother\u2010daughter dyads within brain regions located in the default mode and central executive networks, such as the bilateral anterior cingulate cortex, posterior cingulate cortex, precuneus, middle frontal gyrus, middle temporal gyrus, superior parietal lobule, and left angular gyrus. These similar observations were not identified in other three parent\u2010offspring dyads.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study provides biological evidence for greater vulnerability of daughters, but not sons, in developing depression whose mothers have a history of depression. Our findings extend our knowledge on the pathophysiology of major psychiatric conditions that show sex biases and may contribute to the development of novel interventions targeting high\u2010risk individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13461","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T09:04:22Z","timestamp":1660381462000},"page":"579-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intergenerational concordance of brain structure between depressed mothers and their never\u2010depressed daughters"],"prefix":"10.1111","volume":"76","author":[{"given":"Fusaka","family":"Minami","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinichi","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ueda","sequence":"additional","affiliation":[{"name":"Office of Radiation Technology Keio University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Takamiya","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-5273","authenticated-orcid":false,"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0163-3355","authenticated-orcid":false,"given":"Bun","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.045"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.08.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.4.636"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20430"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.6.1001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1995.tb01363.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.106.3.458"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.01.015"},{"key":"e_1_2_8_10_1","first-page":"176","article-title":"Maternal lifetime depressive\/anxiety disorders and children's internalizing symptoms: The importance of family context","volume":"20","author":"Piche G","year":"2011","journal-title":"J. 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