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This study aims to investigate the diagnosis stability and the potential predictors for progression to schizophrenia in ASD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 11\u2009170 adolescents (10\u201319\u2009years) and young adults (20\u201329\u2009years) with ASD between 2001 and 2010. They were followed up to the end of 2011 to identify newly diagnosed schizophrenia. The Kaplan\u2013Meier method and Cox regression with age as a time scale were employed to estimate incidence rates and the significance of candidate predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The progression rate from ASD to schizophrenia was 10.26% for 10\u2009years of follow\u2010up. Among 860 progressors, 580 (67.44%) occurred within the first 3\u2009years after a diagnosis of ASD. The identified predictors were age (reported as hazard ratio with 95% confidence interval: 1.13; 1.11\u20131.15), depressive disorder (1.36; 1.09\u20131.69), alcohol use disorder (3.05; 2.14\u20134.35), substance use disorder (1.91; 1.18\u20133.09), cluster A personality disorder (2.95; 1.79\u20134.84), cluster B personality disorder (1.86; 1.05\u20133.28), and a family history of schizophrenia (2.12; 1.65\u20132.74).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than two\u2010thirds of the progressors developed schizophrenia within the first 3\u2009years. Demographic characteristics, physical and psychiatric comorbidities, and psychiatric family history were significant predictors of progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.13468","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T14:14:23Z","timestamp":1662214463000},"page":"644-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Diagnostic progression to schizophrenia: A nationwide cohort study of 11\u2009170 adolescents and young adults with autism spectrum disorder"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4136-1251","authenticated-orcid":false,"given":"Tien\u2010Wei","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Kaohsiung Veterans General Hospital Kaohsiung 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