{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:31:53Z","timestamp":1792168313704,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>There is no previous study demonstrating the differences of genome\u2010wide DNA methylation (DNAm) profiles between patients with and without postoperative delirium (POD). We aimed to discover epigenetic (DNAm) markers that are associated with POD in blood obtained from patients before and after neurosurgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pre\u2010 and post\u2010surgical blood DNA samples from 37 patients, including 10 POD cases, were analyzed using the Illumina EPIC array genome\u2010wide platform. We examined DNAm differences in blood from patients with and without POD. Enrichment analysis with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes terms were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When POD cases were tested for DNAm change before and after surgery, enrichment analyses showed many relevant signals with statistical significance in immune response related\u2010pathways and inflammatory cytokine related\u2010pathways such as \u201ccellular response to cytokine stimulus\u201d, \u201cregulation of immune system process\u201d, \u201cregulation of cell activation\u201d, and \u201cregulation of cytokine production\u201d. Furthermore, after excluding the potential effect of common factors related to surgery and anesthesia between POD cases and non\u2010POD controls, the enrichment analyses showed significant signals such as \u201cimmune response\u201d and \u201cT cell activation\u201d, which are same pathways previously identified from an independent non\u2010surgical inpatient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our first genome\u2010wide DNAm investigation of POD showed promising signals related to immune response, inflammatory response and other relevant signals considered to be associated with delirium pathophysiology. Our data supports the hypothesis that epigenetics play an important role in the pathophysiological mechanism of delirium and suggest the potential usefulness of an epigenetics\u2010based biomarker of POD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.13495","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:55:44Z","timestamp":1666313744000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The genome\u2010wide\n                    <scp>DNA<\/scp>\n                    methylation profiles among neurosurgery patients with and without post\u2010operative delirium"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-8997","authenticated-orcid":false,"given":"Takehiko","family":"Yamanashi","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Palo Alto California USA"},{"name":"Department of Psychiatry University of Iowa Carver College of Medicine  Iowa City Iowa USA"},{"name":"Department of Neuropsychiatry Tottori University Faculty of Medicine  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn J.","family":"Crutchley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Carver College of Medicine  Iowa City Iowa USA"},{"name":"University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia E.","family":"Wahba","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Iowa Carver College of Medicine  Iowa City Iowa 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-0181","authenticated-orcid":false,"given":"Masaaki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Tottori University Faculty of Medicine  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Mathew A","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkeun R.","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Public Health University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Iowa Carver College of Medicine  Iowa City Iowa 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