{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:50:11Z","timestamp":1791575411377,"version":"4.3.4"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Impulse control disorders (e.g. pathological gambling, hypersexuality) may develop as adverse reactions to drugs. Pathogenetic hypotheses have mainly focused on D3\u2010receptor agonism, and switching to alternatives with different pharmacologic mechanisms represents a common management strategy. Nonetheless, treatment failure is common and gaining pathophysiological insights is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to identify targets potentially contributing to pathologic impulsivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a pharmacovigilance\u2010pharmacodynamic study on dopamine agonists and antipsychotics using the Food and Drug Administration Adverse Event Reporting System (January 2004\u2013December 2021). We estimated disproportionate reporting using the Bayesian information component. Using online public databases (IUPHAR, ChEMBL, PDSP, DrugBank), we calculated drug occupancies. To identify the targets potentially contributing to impulsivity, we fitted univariate regression models interpolating information components and occupancies within dopamine agonists and antipsychotics. Sensitivity analyses were performed to check for the robustness of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 19\u2009887 reports of impulsivity, 5898 recorded an antipsychotic, and 3100 a dopamine agonist. The more robust signals concerned aripiprazole (N\u00a0=\u00a03091; median information component [95% confidence interval]\u00a0=\u00a04.51[4.45\u20134.55]) and brexpiprazole (229; 4.00[3.78\u20134.16]) for antipsychotics, pergolide (105; 5.82[5.50\u20136.06]) and pramipexole (2009; 5.43[5.36\u20135.48]) for dopamine agonists. Robust, significant positive associations between drug occupancy and impulsivity reporting were found for D3 within dopamine agonists (beta\u00a0=\u00a01.52; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.047) and 5\u2010HT1a within antipsychotics (1.92, 0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results supported the role of D3\u2010receptor agonism in inducing impulsivity in dopamine receptor agonists and identified a potential role of 5\u2010HT1a receptor agonism in antipsychotics. Investigating these receptors may drive towards a better management of drug\u2010induced impulsivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13511","type":"journal-article","created":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T20:27:58Z","timestamp":1669580878000},"page":"160-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Exploring the underlying mechanisms of drug\u2010induced impulse control disorders: a pharmacovigilance\u2010pharmacodynamic study"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-2212","authenticated-orcid":false,"given":"Michele","family":"Fusaroli","sequence":"first","affiliation":[{"name":"Pharmacology Unit, Department of Medical and Surgical Sciences (DIMEC) Universit\u00e0 di Bologna  Bologna 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