{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:23Z","timestamp":1787015963854,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF2014M3C7A1046042"],"award-info":[{"award-number":["NRF2014M3C7A1046042"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI19C0149"],"award-info":[{"award-number":["HI19C0149"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C0630"],"award-info":[{"award-number":["HI18C0630"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["3020200030"],"award-info":[{"award-number":["3020200030"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The neurobiological substrates underlying the relationship of circadian rest\u2010activity rhythm (RAR) alteration with accelerated late\u2010life cognitive decline are not clearly understood. In the present study, the longitudinal relationship of objectively measured circadian RAR with\n                      <jats:italic>in vivo<\/jats:italic>\n                      Alzheimer disease (AD) pathologies and cerebrovascular injury was investigated in older adults without dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The present study included 129 participants without dementia who participated in the KBASE (Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease) cohort. All participants underwent actigraphy at baseline and two consecutive [\n                      <jats:sup>11<\/jats:sup>\n                      C] Pittsburgh compound\u2010B positron emission tomography (PET), [\n                      <jats:sup>18<\/jats:sup>\n                      F] fluorodeoxyglucose\u2010PET, magnetic resonance imaging, and Mini\u2010Mental State Examination (MMSE) at baseline and at a 2\u2010year follow\u2010up assessment. The associations of circadian RAR with annualized change in neuroimaging measures including global amyloid\u2010beta retention, AD\u2010signature region cerebral glucose metabolism (AD\u2010CM), and white matter hyperintensity volume were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Delayed acrophase at baseline was significantly associated with greater annualized decline of AD\u2010CM over a 2\u2010year period, but not with that of other neuroimaging measures. In contrast, other circadian RAR parameters at baseline had no association with annualized change of any neuroimaging measures. Annualized decline of AD\u2010CM was also significantly positively associated with the annual change in MMSE scores. Furthermore, a mediation analysis showed that greater reduction in AD\u2010CM mediated the effect of delayed acrophase at baseline on faster decline of MMSE score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicate that delayed acrophase in late life may cause or predict hypometabolism at AD\u2010signature brain regions, which underlies cognitive decline in the near future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.13521","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T03:05:30Z","timestamp":1671246330000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Circadian rest\u2010activity rhythm and longitudinal brain changes underlying late\u2010life cognitive decline"],"prefix":"10.1111","volume":"77","author":[{"given":"So Yeon","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Psychiatry Chungnam National University Hospital  Daejeon Republic of Korea"},{"name":"Department of Psychiatry Chungnam National University College of Medicine  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Psychiatry Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahyun","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Human Behavioral Medicine Medical Research Centre, Seoul National University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry SMG\u2010SNU Boramae Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine SMG\u2010SNU Boramae Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul\u2010Ho","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University College of Medcine  Seoul South Korea"},{"name":"Department of Radiology Seoul National University Hospital  Seoul 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