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The severity of symptoms and fractional anisotropy (FA) in white matter regions underlying the CMS were assessed at baseline and 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MBCT+PT group showed better outcomes after 2\u2009years than the PT\u2010alone group. The groups showed different FA changes: the MBCT+PT group showed decreased FA in the left anterior cingulate cortex (ACC); the PT\u2010alone group showed increased FA in the bilateral dorsomedial prefrontal cortex, posterior cingulate cortex (PCC), and precuneus. Decreased white matter FA in the ACC, PCC, and precuneus was associated with improvements in the severity of state and trait symptoms in patients with panic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alleviation of excessive white matter connectivity in the CMS after MBCT leads to improvements in clinical symptoms and trait vulnerability in patients with panic disorder. Our study provides new evidence for the long\u2010term benefits of MBCT on white matter plasticity and its clinical applicability as a robust treatment for panic disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13544","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T15:53:26Z","timestamp":1678809206000},"page":"355-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term benefits of mindfulness on white matter tracts underlying the cortical midline structures in panic disorder: A 2\u2010year longitudinal study"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-4014","authenticated-orcid":false,"given":"Minji","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Psychiatry, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai Kiu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7939-3000","authenticated-orcid":false,"given":"Sang\u2010Hyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, CHA Bundang Medical Center CHA University School of Medicine  Seongnam Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199405000-00007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830160021003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00359-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.10106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.7.936"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018555"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-013-0410-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.2011.02024.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/clipsy.bph077"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.6.1454"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2010.03.019"},{"key":"e_1_2_8_13_1","first-page":"2149","article-title":"Effectiveness of mindfulness\u2010based cognitive therapy for positive clinical outcome in panic disorder: A 5\u2010year longitudinal study","volume":"12","author":"Bang M","year":"2021","journal-title":"Mind"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709991747"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.03.016"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2016.07.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.11.026"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207817109"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011043107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.01.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3916"},{"key":"e_1_2_8_23_1","volume-title":"Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders, Research Version, Patient Edition. 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