{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:49:48Z","timestamp":1783385388609,"version":"3.54.6"},"reference-count":77,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["49647"],"award-info":[{"award-number":["49647"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The main aim of this study was to investigate the additional effects of L\u2010theanine, an amino acid in tea and an analog of glutamate with neuroprotective and anti\u2010depressant properties, on obsessive\u2013compulsive disorder (OCD) symptoms in combination with fluvoxamine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from either sex aged between 18 and 60\u2009years diagnosed with OCD, based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM\u20105), who had a Yale\u2010Brown Obsessive Compulsive Scale (Y\u2010BOCS) score of more than 21 were enrolled in a double\u2010blinded, parallel\u2010group, placebo\u2010controlled, clinical trial of 10\u2009weeks to receive either L\u2010theanine (100 mg twice daily) and fluvoxamine (100 mg daily initially followed by 200 mg daily after week 5) or placebo and fluvoxamine. The primary outcome of interest in this study was the Y\u2010BOCS total score decrease from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 95 evaluated patients, 50 completed our study; 30 were randomly assigned to each group. Multivariate analysis (ANOVA) showed a significant effect of time  treatment for L\u2010theanine in obsession subscale (F\u2009=\u20095.51, <jats:italic>P\u2009=<\/jats:italic>\u20090.008) of the Y\u2010BOCS score but not in the total and compulsion scores. Our results showed significantly more improvement in obsession subscale scores in L\u2010theanine compared to placebo group (<jats:italic>P<\/jats:italic>\u2009=\u20090.007, Cohen's d\u2009=\u20090.82). Also, total Y\u2010BOCS scores were lower in L\u2010theanine compared to placebo group at week 5 (<jats:italic>P<\/jats:italic>\u2009=\u20090.039, Cohen's d\u2009=\u20090.60) and 10 (<jats:italic>P<\/jats:italic>\u2009=\u20090.008, Cohen's d\u2009=\u20090.80). However, there was no significant between\u2010group differences in compulsion subscale scores. Complete response was also more frequent in the L\u2010theanine group (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings in this study suggest L\u2010theanine as a relatively safe and effective adjuvant therapy for moderate to severe OCD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13565","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T01:09:56Z","timestamp":1683853796000},"page":"478-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["L\u2010theanine combination therapy with fluvoxamine in moderate\u2010to\u2010severe obsessive\u2013compulsive disorder: A placebo\u2010controlled, double\u2010blind, randomized trial"],"prefix":"10.1111","volume":"77","author":[{"given":"Mehran","family":"Nematizadeh","sequence":"first","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Ghorbanzadeh","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Sanjari","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-3441","authenticated-orcid":false,"given":"Mohammadreza","family":"Shalbafan","sequence":"additional","affiliation":[{"name":"Mental Health Research Center, Psychosocial Health Research Institute (PHRI), Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Boroon","sequence":"additional","affiliation":[{"name":"Mental Health Research Center, Psychosocial Health Research Institute (PHRI), Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir\u2010Abbas","family":"Keshavarz\u2010Akhlaghi","sequence":"additional","affiliation":[{"name":"Mental Health Research Center, Psychosocial Health Research Institute (PHRI), Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-5101","authenticated-orcid":false,"given":"Shahin","family":"Akhondzadeh","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2200"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.003"},{"key":"e_1_2_11_4_1","first-page":"5","article-title":"Practice guideline for the treatment of patients with obsessive\u2010compulsive disorder","volume":"164","author":"Koran LM","year":"2007","journal-title":"Am. 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