{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:51:03Z","timestamp":1776873063455,"version":"3.51.2"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Antepartum depression is a prevalent unhealthy mental health problem worldwide, particularly in low\u2010income countries. It is a major contributor to adverse birth outcomes. Previous studies linking antepartum depression to birthweight have yielded conflicting results, which may be the reason that the depressive symptoms were only measured once during pregnancy. This study aimed to explore the associations between trajectories of antepartum depressive symptoms and birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Depressive symptoms were assessed prospectively at each trimester in 3699 pregnant women from 24 hospitals across 15 provinces in China, using the Edinburgh Postpartum Depression Scale (EPDS). Higher scores of EPDS indicated higher levels of depressive symptoms. Associations between trajectories of depressive symptoms and birthweight were examined using group\u2010based trajectory modeling (GBTM), propensity score\u2010based inverse probability of treatment weighting (IPTW), and logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GBTM identified five trajectories. Compared with the low\u2010stable trajectory of depressive symptoms, only high\u2010stable (OR\u2009=\u20091.35, 95% CI: 1.15\u20132.52) and moderate\u2010rising (OR\u2009=\u20091.18, 95% CI: 1.12\u20131.85) had an increased risk of low birthweight (LBW) in the adjusted longitudinal analysis of IPTW. There was no significant increase in the risk of LBW in moderate\u2010stable and high\u2010falling trajectories. However, trajectories of depressive symptoms were not associated with the risk of macrosomia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antepartum depressive symptoms were not constant. Trajectories of depressive symptoms were associated with the risk of LBW. It is important to optimize and implement screening, tracking, and intervention protocols for antepartum depression, especially for high\u2010risk pregnant women, to prevent LBW.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13590","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T15:28:56Z","timestamp":1693063736000},"page":"631-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trajectories of antepartum depressive symptoms and birthweight: a multicenter and prospective cohort study"],"prefix":"10.1111","volume":"77","author":[{"given":"Jichun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongle","family":"Zhan","sequence":"additional","affiliation":[{"name":"School of Public Health, LKS Faculty of Medicine the University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Tongzhou Maternal and Child Health Hospital of Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology Dongguan Maternal and Child Health Care Hospital  Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Affiliated Hospital of Jining Medical University  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongguo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Perinatal Health Jiaxian Maternal and Child Health Care Hospital  Jiaxian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangkun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2443-911X","authenticated-orcid":false,"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2020.101932"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.87a.19054"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23859"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00247"},{"key":"e_1_2_12_6_1","first-page":"331","article-title":"Reproductive hormone sensitivity and risk for depression across the female life cycle: A continuum of vulnerability?","volume":"33","author":"Soares CN","year":"2008","journal-title":"J. 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