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Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield\u2010specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations with leptin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      T1\u2010weighted magnetic resonance imaging scans were processed using FreeSurfer. We compared 22 left and right hemispheric hippocampal subfield volumes cross\u2010sectionally and longitudinally in females with acute AN (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009165 at baseline,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009110 after partial weight restoration), healthy female controls (HCs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009271), and females after long\u2010term recovery from AN (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200979) using linear models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that most hippocampal subfield volumes were significantly reduced in patients with AN compared with HCs (~\u22123.9%). Certain areas such as the subiculum exhibited no significant reduction in the acute state of AN, while other areas, such as the hippocampal tail, showed strong decreases (~\u22129%). Following short\u2010term weight recovery, most subfields increased in volume. Comparisons between participants after long\u2010term weight\u2010recovery and HC yielded no differences. The hippocampal tail volume was positively associated with leptin levels in AN independent of body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides evidence of differential volumetric differences in hippocampal subfields between individuals with AN and HC and almost complete normalization after weight rehabilitation. These alterations are spatially inhomogeneous and more pronounced compared with other major mental disorders (e.g. major depressive disorder and schizophrenia). We provide novel insights linking hypoleptinemia to hippocampal subfield alterations hinting towards clinical relevance of leptin normalization in AN recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.13626","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T02:50:41Z","timestamp":1701226241000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-0359","authenticated-orcid":false,"given":"Klaas","family":"Bahnsen","sequence":"first","affiliation":[{"name":"Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-6630","authenticated-orcid":false,"given":"Marie\u2010Louis","family":"Wronski","sequence":"additional","affiliation":[{"name":"Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Neuroendocrine Unit, Department of Medicine Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-9857","authenticated-orcid":false,"given":"Johanna Louise","family":"Keeler","sequence":"additional","affiliation":[{"name":"Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neuroscience, Faculty of Medicine Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Department of Psychological Medicine, Institute of Psychiatry, Psychology &amp; 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