{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:36:58Z","timestamp":1790879818225,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101555"],"award-info":[{"award-number":["82101555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Knowledge of how circadian rhythm influences brain health remains limited. We aimed to investigate the associations of accelerometer\u2010measured circadian rest\u2010activity rhythm (CRAR) with incident dementia, cognitive dysfunction, and structural brain abnormalities in the general population and underlying biological mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010seven thousand five hundred and two participants aged over 60\u2009years with accelerometer data were included to investigate the association of CRAR with incidental dementia. Non\u2010parametric CRAR parameters were utilized, including activity level during active periods of the day (M10), activity level during rest periods of the day (L5), and the relative difference between the M10 and L5 (relative amplitude, RA). Associations of CRAR with cognitive dysfunction and brain structure were studied in a subset of participants. Neuroimaging\u2010transcriptomics analysis was utilized to identify the underlying molecular mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 6.86 (4.94\u20138.78) years of follow\u2010up, 494 participants developed dementia. The risk of incident dementia was associated with decreasing M10 (hazard ratio [HR] 1.45; 95% conference interval [CI], 1.28\u20131.64) and RA (HR 1.37; 95% CI, 1.28\u20131.64), increasing L5 (HR 1.14, 95% CI 1.07\u20131.21) and advanced L5 onset time (HR 1.12; 95% CI, 1.02\u20131.23). The detrimental associations were exacerbated by <jats:italic>APOE<\/jats:italic> \u03b54 status and age (&gt;65\u2009years). Decreased RA was associated with lower processing speed (Beta \u22120.04; SE 0.011), predominantly mediated by abnormalities in subcortical regions and white matter microstructure. The genes underlying CRAR\u2010related brain regional structure variation were enriched for synaptic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study underscores the potential of intervention targeting at maintaining a healthy CRAR pattern to prevent dementia risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13671","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T11:29:10Z","timestamp":1714217350000},"page":"393-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Associations between accelerometer\u2010measured circadian rest\u2010activity rhythm, brain structural and genetic mechanisms, and dementia"],"prefix":"10.1111","volume":"78","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Southern Medical University  Guangzhou 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