{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:28:40Z","timestamp":1789417720653,"version":"build-2803163510"},"reference-count":132,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["ZIAMH002927"],"award-info":[{"award-number":["ZIAMH002927"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Vasopressin or arginine\u2010vasopressin (AVP) is a neuropeptide molecule known for its antidiuretic effects and serves to regulate plasma osmolality and blood pressure. The existing literature suggests that AVP plays a multifaceted\u2014though less well\u2010known\u2014role in the central nervous system (CNS), particularly in relation to the pathophysiology and treatment of mood disorders. Animal models have demonstrated that AVP is implicated in regulating social cognition, affiliative and prosocial behaviors, and aggression, often in conjunction with oxytocin. In humans, AVP is implicated in mood disorders through its effects on the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis as well as on the serotoninergic and glutamatergic systems. Measuring plasma AVP has yielded interesting but mixed results in mood and stress\u2010related disorders. Recent advances have led to the development of copeptin as a stable and reliable surrogate biomarker for AVP. Another interesting but relatively unexplored issue is the interaction between the osmoregulatory system and mood disorder pathophysiology, given that psychotropic medications often cause dysregulation of AVP receptor expression or signaling that can subsequently lead to clinical syndromes like syndrome of inappropriate diuresis and diabetes insipidus. Finally, pharmaceutical trials of agents that act on V1a and V1b receptor antagonists are still underway. This narrative review summarizes: (1) the neurobiology of the vasopressinergic system in the CNS; (2) the interaction between AVP and the monoaminergic and glutamatergic pathways in the pathophysiology and treatment of mood disorders; (3) the iatrogenic AVP dysregulation caused by psychotropic medications; and (4) the pharmaceutical development of AVP receptor antagonists for the treatment of mood disorders.<\/jats:p>","DOI":"10.1111\/pcn.13703","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:49:21Z","timestamp":1719377361000},"page":"495-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Arginine vasopressin in mood disorders: A potential biomarker of disease pathology and a target for pharmacologic intervention"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-2736","authenticated-orcid":false,"given":"Hiroe","family":"Hu","sequence":"first","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Carlos A.","family":"Zarate","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Pathophysiology Branch National Institute of Mental Health, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Verbalis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12518"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.10.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00137"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.728810"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-023-00997-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.05.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19080848"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2005.7.3\/fduval"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0539-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.11.016"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054496"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3572-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105665"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2009.05.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.006"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_10"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.034"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.797039"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06930.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109349839"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.09.003"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyab013"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12101561"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.05.017"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S402831"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP086212"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2014.01.010"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.07.025"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S138535"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.08.020"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13256"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2021.110654"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101469"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2009.06.004"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-015-0703-0"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2011"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(96)00294-X"},{"key":"e_1_2_11_39_1","first-page":"109","article-title":"Vasopressin in vascular regulation and water homeostasis in the brain","volume":"59","author":"Kozniewska E","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90463.2008"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00139"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.07.020"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.12.009"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.11.050"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300360"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1309"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001195"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121037119"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170517"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61866-X"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00403-2"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.04.005"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-006-9135-8"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419656"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00520.2013"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.08.007"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2471-x"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(10)82018-7"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-020-00109-3"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13004"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2020.102079"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.08.004"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112077"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2020.104695"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00120-1"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00870-z"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.07.036"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.02.010"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.12.009"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.02.010"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0585-z"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105625"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819182-8.00032-6"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01343-5"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01224-9"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.106"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9705-0_9"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.09.052"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.146"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.03.009"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2079"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3138"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.12.012"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-04-00477.1982"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2014_283"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2020.104878"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2019.104578"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.01.001"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4187-4"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2019.02.002"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819973-2.00003-4"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2004.03.010"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.08.001"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu027"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.07.003"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.12.015"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.10.1189"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0678-0"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.05.005"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2020.170437"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01891"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.10.001"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20208930"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-7"},{"key":"e_1_2_11_105_1","article-title":"Primary polydipsia in the medical and psychiatric patient: Characteristics, complications and therapy","volume":"147","author":"Sailer C","year":"2017","journal-title":"Swiss Med. Wkly."},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0405"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2014.993966"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12412"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.007"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.10.014"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12535"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00453"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2499"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2020.1826430"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610446113"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11090853"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.08.010"},{"key":"e_1_2_11_118_1","article-title":"Mirtazapine risk of hyponatremia and syndrome of inappropriate antidiuretic hormone secretion in adult and elderly patients: A systematic review","volume":"13","author":"Moscona\u2010Nissan A","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.037358"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.01.021"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480349"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640408"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07804"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.628"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4089-5"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113682"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2023.101116"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000388"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.1717"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4735-1"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12699"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2273"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.02.027"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.13703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T06:48:25Z","timestamp":1725346105000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.13703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":132,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/pcn.13703"],"URL":"https:\/\/doi.org\/10.1111\/pcn.13703","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"2024-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}