{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:25:47Z","timestamp":1790961947553,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K21754 to HM"],"award-info":[{"award-number":["19K21754 to HM"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H00492 to KJT"],"award-info":[{"award-number":["22H00492 to KJT"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Autism spectrum disorder (ASD) is associated with abnormal lipid metabolism, such as a high total ratio of omega\u20106 to omega\u20103 in polyunsaturated fatty acids (PUFAs). PUFAs are metabolized to epoxy fatty acids by cytochrome P450 (CYP); then, dihydroxy fatty acid is produced by soluble epoxide hydrolase. This study examined the association between PUFA metabolites in the cord blood and ASD symptoms and adaptive functioning in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study utilized cord blood to quantify PUFA metabolites of the CYP pathway. The Autism Diagnostic Observation Schedule (ADOS\u20102) and Vineland Adaptive Behaviors Scales, Second Edition (VABS\u2010II) were used to assess subsequent ASD symptoms and adaptive functioning in children at 6\u2009years. The analysis included 200 children and their mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Arachidonic acid\u2010derived diols, 11,12\u2010diHETrE was found to impact ASD symptom severity on the ADOS\u20102\u2010calibrated severity scores and impairment in the socialization domain as assessed by the VABS\u2010II (<jats:italic>P<\/jats:italic>\u2009=\u20090.0003; <jats:italic>P<\/jats:italic>\u2009=\u20090.004, respectively). High levels of 11,12\u2010diHETrE impact social affect in ASD symptoms (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), while low levels of 8,9\u2010diHETrE impact repetitive\/restrictive behavior (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Notably, there was specificity in the association between diHETrE and ASD symptoms, especially in girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that the dynamics of diHETrE during the fetal period is important in the developmental trajectory of children after birth. Given that the role of diol metabolites in neurodevelopment <jats:italic>in vivo<\/jats:italic> is completely uncharacterized, the results of this study provide important insight into the role of diHETrE and ASD pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13710","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T08:14:36Z","timestamp":1721722476000},"page":"546-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Arachidonic acid\u2010derived dihydroxy fatty acids in neonatal cord blood relate symptoms of autism spectrum disorders and social adaptive functioning: <scp>Hamamatsu Birth Cohort<\/scp> for <scp>Mothers<\/scp> and <scp>Children<\/scp> (<scp>HBC Study<\/scp>)"],"prefix":"10.1111","volume":"78","author":[{"given":"Takaharu","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Psychiatric and Mental Health Nursing, School of Nursing University of Fukui  Eiheiji Japan"},{"name":"Life Science Innovation Center University of Fukui  Eiheiji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Umeda","sequence":"additional","affiliation":[{"name":"Life Science Innovation Center University of Fukui  Eiheiji Japan"},{"name":"Department of Maternal and Child Health Nursing, School of Nursing University of Fukui  Eiheiji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Harada","sequence":"additional","affiliation":[{"name":"Research Center for Child Mental Development Hamamatsu University School of Medicine  Hamamatsu Japan"},{"name":"United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University and University of Fukui  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Okumura","sequence":"additional","affiliation":[{"name":"Research Center for Child Mental Development Hamamatsu University School of Medicine  Hamamatsu Japan"},{"name":"United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University and University of Fukui  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nakayasu","sequence":"additional","affiliation":[{"name":"Research Center for Child Mental Development Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayo","family":"Ohto\u2010Nakanishi","sequence":"additional","affiliation":[{"name":"Lipidome Lab Co., Ltd.  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