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It is important to clarify which types of long\u2010lasting autism\u2010related symptoms are influenced by childhood experiences to design future intervention studies. However, few studies have examined the association between childhood experiences and autistic symptoms in large samples of adults with ASD and individuals with typical development (TD). In this study, we evaluate the effects of adverse childhood experiences on multiple ASD phenotypes among both individuals with ASD and those with TD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We combined questionnaire evaluations; Childhood Abuse and Trauma Scale, the Japanese version of the Autism\u2010Spectrum Quotient, Conners' Adult ADHD Rating Scale, the Japanese version of the Impact of Event Scale\u2010Revised, and the Japanese version of the Adolescent\/Adult Sensory Profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with ASD and those with TD (<jats:italic>n<\/jats:italic>\u2009=\u2009205 and 104, respectively) were included. There were significant correlations between the extent of adverse childhood experiences and severity of attention\u2010deficit\/hyperactivity disorder symptoms, posttraumatic stress disorder symptoms, and hypersensitivity in both participants with ASD and those with TD. By contrast, ASD core symptoms showed no significant correlation with adverse childhood experiences in either group. These results remained consistent after adjusting for age, sex, and the estimated intelligence quotient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest the need for a detailed disentanglement of ASD\u2010related core and peripheral symptoms of adverse childhood experiences, which may help to appropriately set outcomes for future early interventions for the childhood experiences of individuals with ASD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13712","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T11:10:13Z","timestamp":1721646613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adverse childhood experiences exacerbate peripheral symptoms of autism spectrum disorder in adults"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-7049","authenticated-orcid":false,"given":"Kazuki","family":"Okumura","sequence":"first","affiliation":[{"name":"Department of Psychiatry Nara Medical University School of Medicine  Kashihara Japan"},{"name":"Department of Epidemiology Nara Medical University School of Medicine  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nara Medical University School of Medicine  Kashihara Japan"},{"name":"Department of Psychiatry Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nara Medical University School of Medicine  Kashihara 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