{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:01Z","timestamp":1753879261451,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108014","82071908","82302169"],"award-info":[{"award-number":["82120108014","82071908","82302169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009901","2022YFC2009900","2022YFC209903"],"award-info":[{"award-number":["2022YFC2009901","2022YFC2009900","2022YFC209903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["ZYGX2022YGRH008"],"award-info":[{"award-number":["ZYGX2022YGRH008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M722270"],"award-info":[{"award-number":["2022M722270"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Cerebello\u2010cortical functional dysconnectivity plays a key role in the pathology of schizophrenia (SZ). We aimed to investigate the changes in cerebello\u2010cortical directional connectivity in patients with SZ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 180 drug\u2010na\u00efve patients with first\u2010episode SZ (54 reassessed after 1 year of treatment) and 166 healthy controls (HCs) were included. Resting\u2010state functional magnetic resonance imaging was used to perform Granger causal analysis, in which each of the nine cerebellar functional systems was defined as a seed. The observed effective connectivity (EC) alterations at baseline were further assessed at follow\u2010up and were associated with changes in psychotic symptom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed increased bottom\u2010up EC in first\u2010episode SZ from the cerebellum to the cerebrum (e.g. from the cerebellar attention and cingulo\u2010opercular systems to the bilateral angular gyri, and from the cerebellar cingulo\u2010opercular system to the right inferior frontal gyrus). In contrast, decreased top\u2010down EC in the first\u2010episode SZ was mainly from the cerebrum to the cerebellum (e.g. from the right inferior temporal gyrus, left middle temporal gyrus, left putamen, and right angular gyrus to the cerebellar language system). After 1\u2009year of antipsychotic treatment, information projections from the cerebrum to the cerebellum were partly restored and positively related to symptom remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that decreased top\u2010down EC during the acute phase of SZ may be a state\u2010dependent alteration related to symptoms and medication. However, increased bottom\u2010up EC may reflect a persistent pathological trait.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13715","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T03:58:44Z","timestamp":1722225524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Altered cerebellar effective connectivity in first\u2010episode schizophrenia and long\u2010term changes after treatment"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-7911","authenticated-orcid":false,"given":"Xia","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengyi","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Behavioral Science Feinstein Institutes for Medical Research  Manhasset New York USA"},{"name":"Division of Psychiatry Research Zucker Hillside Hospital  Glen Oaks New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiannan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-1769","authenticated-orcid":false,"given":"Su","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"},{"name":"Huaxi MR Research Center (HMRRC) West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Unit of Psychoradiology Chinese Academy of Medical Sciences  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.conb.2016.06.011","article-title":"The role of the human cerebellum in performance monitoring","volume":"40","author":"Peterburs J","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopsych.2008.01.003","article-title":"The role of the cerebellum in schizophrenia","volume":"64","author":"Andreasen NC","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1038\/s41467-018-06350-7","article-title":"Cerebello\u2010thalamo\u2010cortical hyperconnectivity as a state\u2010independent functional neural signature for psychosis prediction and characterization","volume":"9","author":"Cao H","year":"2018","journal-title":"Nat. Commun."},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/schbul\/sbab112","article-title":"Cerebello\u2010Thalamo\u2010cortical Hyperconnectivity classifies patients and predicts long\u2010term treatment outcome in first\u2010episode schizophrenia","volume":"48","author":"Cao H","year":"2022","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"26124","DOI":"10.1038\/srep26124","article-title":"Patients with first\u2010episode, drug\u2010naive schizophrenia and subjects at ultra\u2010high risk of psychosis shared increased cerebellar\u2010default mode network connectivity at rest","volume":"6","author":"Wang H","year":"2016","journal-title":"Sci. Rep."},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/mp.2017.106","article-title":"Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: A multisite mega\u2010analysis of 983 patients and 1349 healthy controls","volume":"23","author":"Moberget T","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.schres.2018.10.016","article-title":"Altered functional connectivity between sub\u2010regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T","volume":"206","author":"Hua J","year":"2019","journal-title":"Schizophr. Res."},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1525\/9780520350694-015","volume-title":"Contributions to Astronomy and Physics","author":"Wiener N","year":"1956"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/schbul\/sby184","article-title":"Preservation effect: Cigarette smoking acts on the dynamic of influences among unifying neuropsychiatric triple networks in schizophrenia","volume":"45","author":"Liao W","year":"2019","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/mp.2010.46","article-title":"Investigating neural primacy in major depressive disorder: Multivariate granger causality analysis of resting\u2010state fMRI time\u2010series data","volume":"16","author":"Hamilton JP","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/schbul\/sbu126","article-title":"Abnormal causal connectivity by structural deficits in first\u2010episode, drug\u2010naive schizophrenia at rest","volume":"41","author":"Guo W","year":"2015","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fnhum.2018.00456","article-title":"Altered effective connectivity in the default network of the brains of first\u2010episode, drug\u2010Na\u00efve schizophrenia patients with auditory verbal hallucinations","volume":"12","author":"Zhao Z","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001493","article-title":"Increased causal connectivity related to anatomical alterations as potential endophenotypes for schizophrenia","volume":"94","author":"Guo W","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","DOI":"10.1142\/S0129065718500326","article-title":"Aberrant prefrontal\u2010thalamic\u2010cerebellar circuit in schizophrenia and depression: Evidence from a possible causal connectivity","volume":"29","author":"Jiang Y","year":"2019","journal-title":"Int. J. Neural Syst."},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnins.2017.00025","article-title":"Altered Hippocampo\u2010Cerebello\u2010cortical circuit in schizophrenia by a spatiotemporal consistency and causal connectivity analysis","volume":"11","author":"Chen X","year":"2017","journal-title":"Front. Neurosci."},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2019.109837","article-title":"Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole\u2010brain resting\u2010state effective connectivity analysis","volume":"99","author":"Hua M","year":"2020","journal-title":"Prog. Neuro\u2010Psychopharmacol. Biol. Psychiatry"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.neuron.2019.04.021","article-title":"Universal transform or multiple functionality? Understanding the contribution of the human cerebellum across task domains","volume":"102","author":"Diedrichsen J","year":"2019","journal-title":"Neuron"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroimage.2018.10.006","article-title":"Mapping the human brain's cortical\u2010subcortical functional network organization","volume":"185","author":"Ji JL","year":"2019","journal-title":"NeuroImage"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi\u2010modal parcellation of human cerebral cortex","volume":"536","author":"Glasser MF","year":"2016","journal-title":"Nature"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.biopsych.2015.02.008","article-title":"The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: Does the class matter? A meta\u2010analysis and meta\u2010regression of longitudinal magnetic resonance imaging studies","volume":"78","author":"Vita A","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fninf.2016.00047","article-title":"New insights into signed path coefficient granger causality analysis","volume":"10","author":"Zhang J","year":"2016","journal-title":"Front. Neuroinform."},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/schbul\/sbac121","article-title":"Cerebellar functional dysconnectivity in drug\u2010Na\u00efve patients with first\u2010episode schizophrenia","volume":"49","author":"Cao H","year":"2023","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.schres.2005.04.018","article-title":"Determining the chronology and components of psychosis onset: The Nottingham onset schedule (NOS)","volume":"80","author":"Singh SP","year":"2005","journal-title":"Schizophr. Res."},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay SR","year":"1987","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1176\/appi.ajp.2009.09060802","article-title":"International consensus study of antipsychotic dosing","volume":"167","author":"Gardner DM","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"e_1_2_8_27_1","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \u2018pipeline\u2019 data analysis of resting\u2010state fMRI","volume":"4","author":"Chao\u2010Gan Y","year":"2010","journal-title":"Front. Syst. Neurosci."},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2013.08.048","article-title":"Methods to detect, characterize, and remove motion artifact in resting state fMRI","volume":"84","author":"Power JD","year":"2014","journal-title":"NeuroImage"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jneumeth.2011.10.006","article-title":"Granger causality analysis implementation on MATLAB: A graphic user interface toolkit for fMRI data processing","volume":"203","author":"Zang Z\u2010X","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"e_1_2_8_30_1","first-page":"1718","article-title":"Granger causality via vector auto\u2010regression tuned for FMRI data analysis","volume":"17","author":"Chen G","year":"2009","journal-title":"Proc. Intl. Soc. Mag. Reson. Med."},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.biopsych.2022.03.013","article-title":"Cerebellar structure and cognitive ability in psychosis","volume":"92","author":"Moussa\u2010Tooks AB","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-023-01645-y"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","article-title":"The Brain's default mode network","volume":"38","author":"Raichle ME","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.3390\/jcm12093176","article-title":"Widespread intra\u2010 and inter\u2010network dysconnectivity among large\u2010scale resting state networks in schizophrenia","volume":"12","author":"Rong B","year":"2023","journal-title":"J. Clin. Med."},{"key":"e_1_2_8_35_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/schbul\/sbu080","article-title":"Dysconnectivity within the default mode in first\u2010episode schizophrenia: A stochastic dynamic causal modeling study with functional magnetic resonance imaging","volume":"41","author":"Bastos\u2010Leite AJ","year":"2015","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.schres.2016.02.039","article-title":"Putamen\u2010related regional and network functional deficits in first\u2010episode schizophrenia with auditory verbal hallucinations","volume":"173","author":"Cui L\u2010B","year":"2016","journal-title":"Schizophr. Res."},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1176\/appi.neuropsych.17110276","article-title":"Functional and structural connectivity of the cerebellar nuclei with the striatum and cerebral cortex in first\u2010episode psychosis","volume":"31","author":"Lee K\u2010H","year":"2019","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"e_1_2_8_38_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroimage.2011.07.086","article-title":"Cortico\u2010striatal disconnection within the cingulo\u2010opercular network in schizophrenia revealed by intrinsic functional connectivity analysis: A resting fMRI study","volume":"59","author":"Tu P\u2010C","year":"2012","journal-title":"NeuroImage"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/1073858412440596","article-title":"The angular gyrus: Multiple functions and multiple subdivisions","volume":"19","author":"Seghier ML","year":"2013","journal-title":"Neuroscientist"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/jamaneurol.2018.3639","article-title":"Effect of cerebellar stimulation on gait and balance recovery in patients with hemiparetic stroke: A randomized clinical trial","volume":"76","author":"Koch G","year":"2019","journal-title":"JAMA Neurol."},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuroimage.2014.09.002","article-title":"Language and its right\u2010hemispheric distribution in healthy brains: An investigation by repetitive transcranial magnetic stimulation","volume":"102","author":"Sollmann N","year":"2014","journal-title":"NeuroImage"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1162\/089892904322984571","article-title":"The inferior frontal gyrus and phonological processing: An investigation using rTMS","volume":"16","author":"Nixon P","year":"2004","journal-title":"J. Cogn. Neurosci."},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s12311-019-01039-z","article-title":"Language Cerebro\u2010cerebellar reorganization in children after surgery of right cerebellar astrocytoma: A fMRI study","volume":"18","author":"Riva D","year":"2019","journal-title":"Cerebellum"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-244X-11-18","article-title":"Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder","volume":"11","author":"Costafreda SG","year":"2011","journal-title":"BMC Psychiatry"},{"key":"e_1_2_8_45_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fncir.2018.00010","article-title":"The mouse superior colliculus: An emerging model for studying circuit formation and function","volume":"12","author":"Ito S","year":"2018","journal-title":"Front. Neural. Circuit."},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/schbul\/sbaa018","article-title":"New\u2010onset psychosis associated with a lesion localized in the rostral tectum: Insights into pathway\u2010specific connectivity disrupted in psychosis","volume":"46","author":"Koropouli E","year":"2020","journal-title":"Schizophr. Bull."},{"key":"e_1_2_8_47_1","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1038\/npp.2013.168","article-title":"Altered contextual modulation of primary visual cortex responses in schizophrenia","volume":"38","author":"Seymour K","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_8_48_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/NDT.S246163","article-title":"Irreversible primary visual cortex impairment in a mouse model of high\u2010risk schizophrenia","volume":"17","author":"Chen X","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/cne.21243","article-title":"Primary visual cortex volume and total neuron number are reduced in schizophrenia","volume":"501","author":"Dorph\u2010Petersen K\u2010A","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/1352458520922770","article-title":"Resting\u2010state functional connectivity of anterior and posterior cerebellar lobes is altered in multiple sclerosis","volume":"27","author":"Pasqua G","year":"2021","journal-title":"Mult. Scler."},{"key":"e_1_2_8_51_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1176\/appi.ajp.2018.18040429","article-title":"Cerebellar\u2010prefrontal network connectivity and negative symptoms in schizophrenia","volume":"176","author":"Brady RO","year":"2019","journal-title":"Am. J. Psychiatry"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.13715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T03:59:02Z","timestamp":1722225542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.13715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,28]]},"references-count":50,"alternative-id":["10.1111\/pcn.13715"],"URL":"https:\/\/doi.org\/10.1111\/pcn.13715","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"type":"print","value":"1323-1316"},{"type":"electronic","value":"1440-1819"}],"subject":[],"published":{"date-parts":[[2024,7,28]]},"assertion":[{"value":"2023-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pcn.13715"}}