{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:39:45Z","timestamp":1781199585646,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["54718"],"award-info":[{"award-number":["54718"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Current treatments for obsessive\u2010compulsive disorder (OCD) encounter resistance and limiting adverse events, necessitating novel therapeutic strategies. This study aimed to investigate the benefits of naproxen, a medication with effects on inflammation and neuronal function, on OCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and four OCD outpatients with a Yale\u2010Brown Obsessive\u2010Compulsive Scale (Y\u2010BOCS) score of &gt;21 were equally assigned to receive fluoxetine plus either naproxen 250\u2009mg or matched placebo q12hr. Patients were assessed using the Y\u2010BOCS by recording the subscale scores at baseline and weeks 5 and 10 to evaluate efficacy. They were also assessed in terms of tolerability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 96 patients were analyzed. The baseline characteristics were comparable between the groups. There were significant time\u2010treatment interaction effects on the obsession subscale (\u2009=\u20090.055) and total (\u2009=\u20090.043) scores of Y\u2010BOCS. Reductions in the obsession subscale and total scores of Y\u2010BOCS were significantly greater in the fluoxetine plus naproxen group until the endpoint (Cohen's <jats:italic>d<\/jats:italic>\u2009=\u20090.560 and Cohen's <jats:italic>d<\/jats:italic>\u2009=\u20090.477, respectively). However, the difference in compulsion subscale score changes between the groups was not significant. Respondents with a reduction of \u226535% in Y\u2010BOCS total scores were significantly more in the fluoxetine plus naproxen group (80.0% <jats:italic>versus<\/jats:italic> 47.8%). The side effect frequencies were comparable between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Naproxen, adjunct to fluoxetine, outperformed adjunctive placebo in treating obsession and total symptoms of OCD patients in a safe and tolerable manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>The study protocol was registered and published in the Iranian Registry of Clinical Trials (http:\/\/www.irct.ir; registration number IRCT20090117001556N139).<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13748","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:38:42Z","timestamp":1727843922000},"page":"810-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Naproxen adjunct to fluoxetine for moderate\u2010to\u2010severe obsessive\u2010compulsive disorder: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-2827","authenticated-orcid":false,"given":"Ahmad","family":"Shamabadi","sequence":"first","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Motavalian","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalda","family":"Farahmand","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Farahmand","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razman","family":"Arabzadeh Bahri","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Askari","sequence":"additional","affiliation":[{"name":"Mental Health Research Center, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Ansari","sequence":"additional","affiliation":[{"name":"Psychosomatic Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadali","family":"Fallahzadeh","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammdreza","family":"Shalbafan","sequence":"additional","affiliation":[{"name":"Mental Health Research Center, Psychosocial Health Research Institute, Department of Psychiatry, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-5101","authenticated-orcid":false,"given":"Shahin","family":"Akhondzadeh","sequence":"additional","affiliation":[{"name":"Psychiatric Research Center, Roozbeh Psychiatric Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180813155017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2010.12.2\/mkellner"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.11.028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.1567"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.04.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3746"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1042-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.07.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.137018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2022.152352"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-054296"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3T886"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-7508-8_26"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1549929"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0437"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.2000.1147"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.01.019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.32598\/bcn.2021.1998.1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S255375"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2016.0179"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2016.0193"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.01.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72352"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_8_26_1","volume-title":"Association SRAP","author":"First M","year":"2015"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"e_1_2_8_28_1","volume-title":"Multi\u2010Drug Interaction Checker","author":"Medscape\u00ae L","year":"2017"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2016.01.007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/11635850-000000000-00000"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m07789"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000745"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.215"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1409-x"},{"key":"e_1_2_8_36_1","article-title":"Obsessive\u2010compulsive disorder with rheumatological and inflammatory diseases: A systematic review","volume":"13","author":"Alsheikh AM","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_8_37_1","volume-title":"Naproxen","author":"Brutzkus JC","year":"2024"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19ac13182"},{"key":"e_1_2_8_39_1","article-title":"Disrupted functional connectivity of the amygdala predicts the efficacy of non\u2010steroidal anti\u2010inflammatory drugs in Migraineurs without Aura","volume":"15","author":"Wei H\u2010L","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-04115-z"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171800079X"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2008.20.4.390"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-45"},{"key":"e_1_2_8_44_1","volume-title":"Fluoxetine","author":"Sohel AJ","year":"2024"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18654-2"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20589"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.03.033"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23884"}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.13748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T06:37:33Z","timestamp":1733207853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.13748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/pcn.13748"],"URL":"https:\/\/doi.org\/10.1111\/pcn.13748","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}