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The possible specificity of treatment\u2010resistant depression (TRD) neurobiology is still under investigation, with risk factors such as higher inflammatory markers being identified. Given recent findings on the role of choroid plexus (ChP) in neuroinflammation and hippocampus in treatment response, the aim of the present study was to evaluate inflammatory\u2010 and trophic\u2010related differences in these regions along with ventricular volumes among patients with treatment\u2010sensitive depression (TSD), TRD, and healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ChP, hippocampal, and ventricular volumes were assessed in 197 patients with MDD and 58 age\u2010 and sex\u2010matched HCs. Volumes were estimated using FreeSurfer 7.2. Treatment resistance status was defined as failure to respond to at least two separate antidepressant treatments. Region of interest volumes were then compared among groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found higher ChP volumes in patients with TRD compared with patients with TSD and HCs. Our results also showed lower hippocampal volumes and higher lateral ventricular volumes in TRD compared with both patients without TRD and HCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings corroborate the link between TRD and neuroinflammation, as ChP volume could be considered a putative marker of central immune activity. The lack of significant differences in all of the region of interest volumes between patients with TSD and HCs may highlight the specificity of these features to TRD, possibly providing new insights into the specific neurobiological underpinnings of this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pcn.13764","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T06:20:19Z","timestamp":1732083619000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment\u2010resistant major depressive disorder"],"prefix":"10.1111","volume":"79","author":[{"given":"Beatrice","family":"Bravi","sequence":"first","affiliation":[{"name":"Psychiatry &amp; Clinical Psychobiology, Division of Neuroscience IRCCS San Raffaele Hospital  Milan Italy"},{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5731-5925","authenticated-orcid":false,"given":"Marco","family":"Paolini","sequence":"additional","affiliation":[{"name":"Psychiatry &amp; Clinical Psychobiology, Division of Neuroscience IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Maccario","sequence":"additional","affiliation":[{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"},{"name":"Mood Disorders Unit IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Milano","sequence":"additional","affiliation":[{"name":"Psychiatry &amp; Clinical Psychobiology, Division of Neuroscience IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"Psychiatry &amp; Clinical Psychobiology, Division of Neuroscience IRCCS San Raffaele Hospital  Milan Italy"},{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Maria Teresa","family":"Melloni","sequence":"additional","affiliation":[{"name":"Psychiatry &amp; Clinical Psychobiology, Division of Neuroscience IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Zanardi","sequence":"additional","affiliation":[{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"},{"name":"Mood Disorders Unit IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Colombo","sequence":"additional","affiliation":[{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"},{"name":"Mood Disorders Unit IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4949-856X","authenticated-orcid":false,"given":"Francesco","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Psychiatry &amp; Clinical Psychobiology, Division of Neuroscience IRCCS San Raffaele Hospital  Milan Italy"},{"name":"University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01381-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.06.045"},{"key":"e_1_2_9_4_1","first-page":"26","article-title":"The burden of disease for treatment\u2010resistant depression","volume":"62","author":"Greden JF","year":"2001","journal-title":"J. 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