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More recently among these, functional neurosurgical techniques using high\u2010 and low\u2010intensity focused ultrasound (FUS) have emerged as promising options in this arena, largely due to their minimally\u2010invasive nature and encouraging early safety and efficacy data. Existing clinical data have thus far demonstrated FUS to be a potentially useful intervention for treatment\u2010refractory forms of obsessive\u2013compulsive disorder, major depressive disorder, various anxiety disorders, substance\u2010use disorder, and schizophrenia. This report presents a comprehensive review of existing clinical trial data, summarizing key findings, study specifications, and providing critical analysis. 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