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An important issue is identifying psychosis\u2010specific neuro\u2010cognitive dysfunctions. We addressed this issue by studying patterns of relationships between cognition and multiple other measures in persons with psychosis, their first\u2010degree biological relatives, and healthy individuals (largest possible\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092826).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Brief Assessment of Cognition and Wide Range Achievement Test estimated cognitive performance. Neuroanatomical measures were FreeSurfer parcellations of 3T MRI structural brain scans. Brain functioning measures included saccades, smooth pursuit eye movements, stop signal, EEG, ERPs, resting state fMRI, plus clinical characteristics. Overall associations between 452 measures of brain structure\u2013function and clinical characteristics (predictors) with cognitive performance (criterion) were estimated using the High Dimensional Empirical Bayes Screening algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The model yielded a common slope of predictors on cognitive performance (slope\u2009=\u20090.18,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.33,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The majority (85%) of predictors fit this function, called the BAsic NeuroCognitive Continuum (BANCC). This relationship was stronger for psychosis probands (slope\u2009=\u20090.20,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.38) than for relatives (slope\u2009=\u20090.09,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.17) and healthy persons (slope\u2009=\u20090.11,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.22). There were predictor\u2010specific deviations from the common slope. Variables more strongly associated with cognitive performance (frontal\u2010temporal\u2013parietal lobe volumes, hippocampal regions, antisaccade performance) may tap neural architecture common to primary psychosis pathology. Variables unrelated to cognitive performance (intrinsic neural activity, volumes of lateral thalamic nuclei) distinguish specific neurophysiologically defined B\u2010SNIP psychosis Biotypes and may capture signatures of psychosis pathophysiology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>BANCC is identifiable across humans, but deviations from that common attribute identify features of brain structure\u2013function perhaps most central and specific to psychosis\u2010related pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.13887","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:59:22Z","timestamp":1756191562000},"page":"747-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The BAsic\n                    <scp>NeuroCognitive<\/scp>\n                    Continuum (\n                    <scp>BANCC<\/scp>\n                    ): Delineation of dimensional and categorical features for etiological and treatment investigations of idiopathic psychosis"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9442-7012","authenticated-orcid":false,"given":"Hailey C.","family":"Warren","sequence":"first","affiliation":[{"name":"Departments of Psychology and Neuroscience, BioImaging Research Center University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Parker","sequence":"additional","affiliation":[{"name":"Departments of Psychology and Neuroscience, BioImaging Research Center University of Georgia  Athens Georgia USA"},{"name":"Department of Human Genetics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah L.","family":"Trotti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashwath","family":"Meda","sequence":"additional","affiliation":[{"name":"Olin Neuropsychiatry Research Center, Institute of Living  Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka","family":"Lencer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Institute for Translational Psychiatry Universit\u00e4t M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sprenger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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