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The outcome was defined as the absence of a hypnotic prescription for 90 consecutive days after the final prescription. Kaplan\u2013Meier and Cox proportional hazards analyses were used to compare the hazards of discontinuing hypnotics among four classes: benzodiazepines, non\u2010benzodiazepines, dual orexin receptor antagonists, and melatonin receptor agonists, adjusting for age, sex, and the number of diagnostic categories based on the International Statistical Classification of Diseases, Tenth Revision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Kaplan\u2013Meier analysis revealed significant differences among the hypnotic classes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), with dual orexin receptor antagonists demonstrating the highest rate of discontinuation. Multivariable Cox regression indicated a significantly higher likelihood of discontinuing dual orexin receptor antagonists than that of benzodiazepines (hazard ratio\u2009=\u20091.40;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Older age (hazard ratio\u2009=\u20090.995;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a higher number of International Statistical Classification of Diseases, Tenth Revision diagnostic categories (hazard ratio\u2009=\u20090.975;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) were significantly associated with a lower likelihood of discontinuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dual orexin receptor antagonists are more likely to be discontinued than benzodiazepines after continuous hypnotic prescription, highlighting their potential clinical utility in insomnia treatment.<\/jats:p>\n                  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