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The thalamus plays an important role in MDD by connecting large areas of the brain. Here, we explored thalamic connectivity in MDD at the subnuclear level using ultra\u2010high\u2010field MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We combined ultra\u2010high\u2010field functional and diffusion MRI at 7.0 Tesla to map the connectivity of thalamic subnuclei in MDD patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913). We segmented thalamic subnuclei and calculated the functional and structural connectivity of thalamic subnuclei and tested for group differences and associations with clinical characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MDD patients showed increased functional connectivity of the right thalamic central lateral nucleus with the right amygdala, bilateral inferior occipital lobe, and right transverse temporal gyrus, which was accompanied by increased structural connectivity between the right thalamic central lateral nucleus and the right inferior occipital lobe. Medicated MDD patients had a greater streamline count of the right thalamic central lateral nucleus\u2013right inferior occipital lobe tract than healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thalamic subnuclear connectivity with cortical and subcortical brain regions is perturbed in MDD. These results further support increased thalamic connectivity in MDD and suggest that this is related to a specific subnucleus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.70048","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:40:37Z","timestamp":1773218437000},"page":"477-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7\u2009Tesla"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6919-8017","authenticated-orcid":false,"given":"Weijian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Psychiatry Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"},{"name":"Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006) Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution &amp; Animal Models, National Research Facility for Phenotypic &amp; Genetic Analysis of Model Animals (Primate Facility), National Resource Center for Non\u2010Human Primates, Kunming Institute of Zoology Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurjen","family":"Heij","sequence":"additional","affiliation":[{"name":"Spinoza Centre for Neuroimaging KNAW  Amsterdam The Netherlands"},{"name":"Netherlands Institute for Neuroscience KNAW  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens A.","family":"van de Mortel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Amsterdam UMC Location University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Liebrand","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Department of Radiation Oncology Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthan","family":"Caan","sequence":"additional","affiliation":[{"name":"Amsterdam Neuroscience  Amsterdam The Netherlands"},{"name":"Department of Biomedical Engineering &amp; Physics Amsterdam UMC location University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wietske","family":"van der Zwaag","sequence":"additional","affiliation":[{"name":"Spinoza Centre for Neuroimaging KNAW  Amsterdam The Netherlands"},{"name":"Netherlands Institute for Neuroscience KNAW  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"J. 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