{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:17:12Z","timestamp":1783167432677,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102314\u2010B\u2010038\u2010096\u2010MY3"],"award-info":[{"award-number":["113\u20102314\u2010B\u2010038\u2010096\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113\u20102628\u2010B\u2010038\u2010010\u2010MY3"],"award-info":[{"award-number":["113\u20102628\u2010B\u2010038\u2010010\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX114\u201011431NI"],"award-info":[{"award-number":["NHRI\u2010EX114\u201011431NI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data\u2010driven, unbiased approach to uncover biological alterations. Blood platelets provide a stable and comprehensive reflection of the body's internal milieu. This proof\u2010of\u2010concept study explores platelet proteomic alterations in mania.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      High\u2010resolution proteomic profiling was performed on platelet samples from hospitalized patients with severe mania (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) and 1:1 age\u2010 and sex\u2010matched healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) using liquid chromatography\u2013tandem mass spectrometry. Platelet proteins were quantified, differentially expressed proteins identified, and functional enrichment analyses conducted to characterize associated biological pathways. Key proteomic predictions were validated by enzyme\u2010linked immunosorbent assay (ELISA) in platelet and plasma samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Proteomic analysis revealed that mania is associated with proteins primarily enriched in immune activation while lacking those enriched in cell homeostasis. Among shared proteins, mania exhibited a prominent cluster of downregulated proteins, primarily converging on immune\u2010related pathways. The most robust alteration involved deficits in MHC Class I\u2010mediated antigen processing. Key immune regulatory hubs \u2013 transforming growth factor (TGF)\u2010\u03b2 and interleukin\u20104 (IL\u20104) \u2013 were identified, with the association of increased TGF\u2010\u03b2 levels with mania validated by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights platelet proteomics as a valuable tool for investigating biological alterations in psychiatric disorders. Our findings indicate deficits in MHC Class I\u2010related pathways and immune alterations consistent with chronic low\u2010grade inflammation, suggesting potential roles for latent viral and autoimmune\u2010related mechanisms in BD. These results support and refine the concept of immune dysregulation in mania and BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.70055","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:14:38Z","timestamp":1775301278000},"page":"575-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune dysregulation in mania: A proof\u2010of\u2010concept platelet proteomics study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-4819","authenticated-orcid":false,"given":"Paola","family":"Magioncalda","sequence":"first","affiliation":[{"name":"International Master\/Ph.D. Program in Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Mind Brain and Consciousness Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Martino","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind Brain and Consciousness Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhi Thao Ngoc","family":"Le","sequence":"additional","affiliation":[{"name":"International PhD Program in Biomedical Engineering, College of Biomedical Engineering Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8626-6472","authenticated-orcid":false,"given":"Wen\u2010Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei City Psychiatric Center (TCPC) Taipei City Hospital Songde Branch  Taipei Taiwan"},{"name":"School of Medicine, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Taipei City Psychiatric Center (TCPC) Taipei City Hospital Songde Branch  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blum","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, UMR\u2010S1172 Lille Neuroscience &amp; Cognition (LilNCog)  Lille France"},{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Burnouf","sequence":"additional","affiliation":[{"name":"Graduate Institute of Mind Brain and Consciousness Taipei Medical University  Taipei Taiwan"},{"name":"International PhD Program in Biomedical Engineering, College of Biomedical Engineering Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Diagnostic and Statistical Manual for Mental Disorders","author":"APA","year":"2013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2008.07.006"},{"key":"e_1_2_9_4_1","first-page":"2008","volume-title":"Update","author":"WHO. 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