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Twin studies have shown that BD is highly heritable, with estimates ranging from 60% to 90%. However, our understanding of this genetic component has yet to be translated into clinical interventions or prediction tools. In this review, we summarize findings from large\u2010scale international collaborations, with the latest and largest study finding 298 genome\u2010wide significant loci and 36 credible mapped genes associated with BD, alongside the first genes with an increased burden of rare genetic variants. We next highlight key biological insights from these findings, including widespread genetic overlap but distinct patterns of genetic correlation with other mental disorders and related traits; enrichment of gene expression within both brain\u2010specific tissues and cell types and non\u2010brain tissues, including pancreatic and large intestinal tissues; and the identification of novel drug targets and repurposing candidates, including calcium channel blockers. 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