{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:56:00Z","timestamp":1791568560806,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 115\u20102314\u2010B\u2010006\u2010023"],"award-info":[{"award-number":["NSTC 115\u20102314\u2010B\u2010006\u2010023"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 115\u20102314\u2010B\u2010006\u2010034\u2010MY3"],"award-info":[{"award-number":["NSTC 115\u20102314\u2010B\u2010006\u2010034\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX114\u201011420NC"],"award-info":[{"award-number":["NHRI\u2010EX114\u201011420NC"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX115\u201011420NC"],"award-info":[{"award-number":["NHRI\u2010EX115\u201011420NC"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There is a critical need for objective biomarkers that can link peripheral assays to central neural network dysfunction. We investigated blood neurofilament light chain (NfL), a marker of axonal injury, and C\u2010reactive protein (CRP), a marker of systemic inflammation, in relation to the brain network topology and microstructural integrity in methamphetamine use disorder (MUD), a paradigm of acquired neurotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010two male MUD patients and 44 male controls received diffusion and resting\u2010state functional magnetic resonance imaging and underwent analysis of blood NfL and CRP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to controls, MUD patients exhibited significantly elevated blood NfL and CRP levels, as well as salience\u2010network dysfunction and microstructural abnormality. Furthermore, higher NfL levels were associated with lower local efficiency (segregation) in the right anterior insula and higher mean diffusivity in the right insula and supramarginal gyrus, supporting a link with axonal injury. By contrast, higher CRP levels were associated with integration\u2010related graph measures in the bilateral supramarginal gyrus, suggesting that systemic inflammation may also be relevant to salience\u2010network dysfunction in MUD. Crucially, the correlation involving NfL levels remained significant after controlling for the duration of methamphetamine use, and higher baseline NfL levels were significantly correlated with greater urine positivity rates during one\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Blood NfL was associated with both functional and microstructural abnormalities of the salience network and potentially associated with relapse vulnerability in MUD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.70122","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:21:16Z","timestamp":1788157276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Blood Neurofilament Light Chain as a Biomarker of Central Network Dysregulation in Methamphetamine Use Disorder: A Multi\u2010Modal Investigation with Clinical Implications"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-2434","authenticated-orcid":false,"given":"Shyh\u2010Yuh","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-2965","authenticated-orcid":false,"given":"Yu\u2010Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Research National Health Research Institutes  Zhunan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5213-1585","authenticated-orcid":false,"given":"Huai\u2010Hsuan","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Behavioral Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Behavioral Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-9636","authenticated-orcid":false,"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Behavioral Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Yang","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program National Institutes of Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-9967","authenticated-orcid":false,"given":"Tzu\u2010Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/wps.21078","article-title":"Candidate biomarkers in psychiatric disorders: State of the field","volume":"22","author":"Abi\u2010Dargham A","year":"2023","journal-title":"World Psychiatry"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ijnp\/pyaf025","article-title":"Moving toward precision and personalized treatment strategies in psychiatry","volume":"28","author":"Comai S","year":"2025","journal-title":"Int. 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