{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T12:21:02Z","timestamp":1788006062791,"version":"build-2784847793"},"reference-count":106,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171508"],"award-info":[{"award-number":["82171508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ60706"],"award-info":[{"award-number":["2025JJ60706"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the frontal\u2010limbic overmodulation model and the defense cascade model) have been proposed to interpret dissociative symptoms, heterogeneous regional\u2010level imaging findings impede our comprehension of the neural changes underlying dissociative symptoms across diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the functional connectivity network mapping method, this study systematically screened 45 cross\u2010diagnostic reports of dissociation\u2010related structural and functional brain changes. By integrating resting\u2010state imaging data from healthy individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009872), we constructed dissociative task\u2010induced activation, gray matter volume (GMV), and resting\u2010state activity impairment networks. Additionally, we performed spatial correlation analyses between the damage networks and 19 neurotransmitter distribution maps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The task\u2010induced damage network showed the largest proportional overlap with the anterior salience network (SN, 12.25%), basal ganglia network (BGN, 13.57%), and dorsal default mode network (DMN, 17.74%). For the GMV damage network, the main overlap proportions were observed with the dorsal DMN (12.33%) and the anterior SN (7.67%). The resting\u2010state activity damage network showed the greatest overlap with the anterior SN (5.17%), posterior SN (5.73%), auditory (5.47%), and sensorimotor network (4.50%). Spatial correlation analyses found associations between network changes and the distribution of N\u2010methyl\u2010D\u2010aspartate receptors, vesicular acetylcholine transporter, cannabinoid receptor CB1, serotonin transporter, and mu\u2010opioid receptor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study further elucidated the neuroimaging changes underlying across\u2010diagnostic dissociation and provided new insights for identifying network intervention targets to improve dissociative symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.70125","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T12:12:33Z","timestamp":1788005553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Network Convergence of Abnormal Gray Matter and Functional Activity of Pathological Dissociative Symptoms"],"prefix":"10.1111","author":[{"given":"Xuhan","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0691-8057","authenticated-orcid":false,"given":"Yangpan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-2465","authenticated-orcid":false,"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-clinpsy-050212-185531","article-title":"Dissociative disorders in DSM\u20105","volume":"9","author":"Spiegel D","year":"2013","journal-title":"Annu. 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