{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:11:49Z","timestamp":1788757909863,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1A2C1102105"],"award-info":[{"award-number":["NRF\u20102020R1A2C1102105"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"abstract":"\n Aim<\/jats:title>\n Somatic symptom disorder (SSD) is a functional disorder characterized by dysregulated neural processing of bodily signals. However, the neural mechanisms underlying recovery versus chronicity in SSD remain unclear. We investigated hierarchical neurophysiological features associated with symptom persistence and improvement using longitudinal source\u2010localized electroencephalography (EEG).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Resting\u2010state EEG was analyzed in 83 patients with SSD and 80 matched healthy controls, with 76 participants completing a 6\u2010month follow\u2010up. We examined longitudinal changes in source\u2010localized spectral power and network efficiency in relation to somatic and affective symptom trajectories.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients showed a significant reduction in somatic symptoms (\n P<\/jats:italic>\n \u2009<\u20090.001) over time. SSD featured a persistent deficit in Gamma\u2010band global efficiency (\n P<\/jats:italic>\n \u2009=\u20090.035) that remained lower than healthy levels (\n P<\/jats:italic>\n \u2009=\u20090.972 for interaction), representing residual neurobiological vulnerability. Conversely, thalamic spectral power exhibited significant group\u2009\u00d7\u2009time interactions (\n P<\/jats:italic>\n \u2009<\u20090.05), reflecting longitudinal subcortical changes. Symptomatic relief was specifically associated with nodal efficiency reorganization within the left central sensorimotor region (Beta band,\n r<\/jats:italic>\n \u2009=\u2009\u22120.54,\n P<\/jats:italic>\n \u2009<\u20090.001). These associations remained robust after controlling for depression and anxiety, with mediation analyses indicating that these associations were largely independent of affective fluctuations.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n SSD involves a multilayered neurobiological architecture, where persistent network\u2010level limitations coexist with longitudinal subcortical and cortical changes. While broader functional deficits endure, clinical recovery is accompanied by longitudinal thalamic changes and is more directly associated with localized sensorimotor reorganization. These findings suggest that addressing both persistent network differences and longitudinal recovery\u2010related changes is essential for effective SSD management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pcn.70127","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:27:12Z","timestamp":1788755232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional network reorganization and thalamocortical gating as neurobiological markers of recovery in somatic symptom disorder: A 6\u2010month longitudinal source EEG study"],"prefix":"10.1111","author":[{"given":"Yuna","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Psychiatry Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EKyong","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Bundang Hospital Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Youn","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Seoul National University Bundang Hospital Seongnam South Korea"},{"name":"Department of Psychiatry Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1474-4422(21)00422-1","article-title":"Functional neurological disorder: New subtypes and shared mechanisms","volume":"21","author":"Hallett M","year":"2022","journal-title":"Lancet Neurol."},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1017\/S0033291721004177","article-title":"Somatic symptom disorder: A scoping review on the empirical evidence of a new diagnosis","volume":"52","author":"L\u00f6we B","year":"2022","journal-title":"Psychol. Med."},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/PSY.0000000000000490","article-title":"Features of resting\u2010state electroencephalogram theta coherence in somatic symptom disorder compared with major depressive disorder: A pilot study","volume":"79","author":"Ahn J","year":"2017","journal-title":"Psychosom. Med."},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.comppsych.2021.152265","article-title":"Persistence rate of DSM\u20105 somatic symptom disorder: 4\u2010year follow\u2010up in patients from a psychosomatic outpatient clinic","volume":"110","author":"Behm AC","year":"2021","journal-title":"Compr. Psychiatry"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271717","article-title":"Interoceptive accuracy and bias in somatic symptom disorder, illness anxiety disorder, and functional syndromes: A systematic review and meta\u2010analysis","volume":"17","author":"Wolters C","year":"2022","journal-title":"PLoS One"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.32872\/cpe.v1i4.35952","article-title":"Symptom perception from a predictive processing perspective","volume":"1","author":"Pezzulo G","year":"2019","journal-title":"Clin. Psychol. Eur."},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2024.02.017","article-title":"Affective dysfunction mediates the link between neuroimmune markers and the default mode network functional connectivity, and the somatic symptoms in somatic symptom disorder","volume":"118","author":"Park B","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/jnnp-2018-319657","article-title":"Corticolimbic fast\u2010tracking: Enhanced multimodal integration in functional neurological disorder","volume":"90","author":"Diez I","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2022.111489","article-title":"Increased spontaneous fronto\u2010central oscillatory power during eye closing in patients with multiple somatic symptoms","volume":"324","author":"Ma X","year":"2022","journal-title":"Psychiatry Res. Neuroimaging."},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2021.110637","article-title":"Longitudinal qEEG changes correlate with clinical outcomes in patients with somatic symptom disorder","volume":"151","author":"Hong JK","year":"2021","journal-title":"J. Psychosom. Res."},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clinph.2018.09.027","article-title":"Electrophysiological evidence for changes in attentional orienting and selection in functional somatic symptoms","volume":"130","author":"Karlinski M","year":"2019","journal-title":"Clin. Neurophysiol."},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1590127","article-title":"The role of sensory attenuation in symptomatic and healthy individuals: A scoping review","volume":"19","author":"Rossi L","year":"2025","journal-title":"Front. Neurosci."},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"fcaf195","DOI":"10.1093\/braincomms\/fcaf195","article-title":"Delineating network integration and segregation in the pathophysiology of functional neurological disorder","volume":"7","author":"Westlin C","year":"2025","journal-title":"Brain Commun."},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.817527","article-title":"A longitudinal study on attenuated structural covariance in patients with somatic symptom disorder","volume":"13","author":"Park HY","year":"2022","journal-title":"Front. Psychiatry."},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.31887\/DCNS.2018.20.1\/phenningsen","article-title":"Management of somatic symptom disorder","volume":"20","author":"Henningsen P","year":"2018","journal-title":"Dialogues Clin. Neurosci."},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1672542","article-title":"Brain network properties in chronic pain\u2014A systematic review and meta\u2010analysis of graph\u2010based connectivity metrics","volume":"19","author":"Butry L","year":"2025","journal-title":"Front. Neurosci."},{"key":"e_1_2_12_19_1","volume-title":"User's Guide for the SCID\u20105\u2010CV: Structured Clinical Interview for DSM\u20105 Disorders: Clinician Version","author":"First MB","year":"2016"},{"key":"e_1_2_12_20_1","first-page":"580","article-title":"Psychometric properties of the patient health questionnaire\u201315 (PHQ\u201315) for measuring the somatic symptoms of psychiatric outpatients","volume":"50","author":"Han C","year":"2009","journal-title":"Psychosomatics"},{"key":"e_1_2_12_21_1","first-page":"8","volume-title":"Korean Manual of Symptom Checklist\u201090\u2010Revision","author":"Kim K\u2010I","year":"1984"},{"key":"e_1_2_12_22_1","first-page":"48","article-title":"The validation study of Beck depression scale 2 in Korean version","volume":"7","author":"Lim S\u2010Y","year":"2011","journal-title":"Anxiety Mood."},{"key":"e_1_2_12_23_1","first-page":"185","article-title":"A clinical study on the Korean version of Beck anxiety inventory: Comparative study of patient and non\u2010patient","volume":"16","author":"Yook SP","year":"1997","journal-title":"Korean J. Clin. Psychol."},{"key":"e_1_2_12_24_1","first-page":"18","article-title":"The case of college students: Korean adaptation of the state\u2010trait anger expression inventory (STAXI\u2010K)","volume":"3","author":"Chon K","year":"1998","journal-title":"Korean J. Health Psychol."},{"key":"e_1_2_12_25_1","first-page":"77","article-title":"Comparison of reliability and validity of three Korean versions of the 20\u2010item Toronto alexithymia scale","volume":"11","author":"Chung U\u2010S","year":"2003","journal-title":"Korean J. Psychosom. Med."},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/hbm.10061","article-title":"Validating the boundary element method for forward and inverse EEG computations in the presence of a hole in the skull","volume":"17","author":"Oostenveld R","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: Uses and interpretations","volume":"52","author":"Rubinov M","year":"2010","journal-title":"Neuroimage"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjno-2025-001032","article-title":"Shared neural signatures in functional neurological disorder and chronic pain: A multimodal narrative review","volume":"7","author":"Kannan S","year":"2025","journal-title":"BMJ Neurol. Open."},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41467-018-02820-0","article-title":"Thalamocortical dysrhythmia detected by machine learning","volume":"9","author":"Vanneste S","year":"2018","journal-title":"Nat. Commun."},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149085","article-title":"Electroencephalographic patterns in chronic pain: A systematic review of the literature","volume":"11","author":"Pinheiro ESS","year":"2016","journal-title":"PLoS One"},{"key":"e_1_2_12_31_1","article-title":"Thalamocortical mechanisms underlying real and imagined acupuncture","volume":"11","author":"Kong Q","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1011595","article-title":"Rhythmic modulation of prediction errors: A top\u2010down gating role for the beta\u2010range in speech processing","volume":"19","author":"Hovsepyan S","year":"2023","journal-title":"PLoS Comput. Biol."},{"key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.tics.2024.03.010","article-title":"Beta: Bursts of cognition","volume":"28","author":"Lundqvist M","year":"2024","journal-title":"Trends Cogn. Sci."},{"key":"e_1_2_12_34_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105062","article-title":"Gamma\u2010band oscillations of pain and nociception: A systematic review and meta\u2010analysis of human and rodent studies","volume":"146","author":"Li Z","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"e_1_2_12_35_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2023.1073537","article-title":"Hierarchical predictive coding in distributed pain circuits","volume":"17","author":"Chen ZS","year":"2023","journal-title":"Front. Neural Circuits"},{"key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41386-021-01132-0","article-title":"The role of prefrontal cortex in cognitive control and executive function","volume":"47","author":"Friedman NP","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_12_37_1","doi-asserted-by":"crossref","DOI":"10.1111\/psyp.12879","article-title":"On the role of asymmetric frontal cortical activity in approach and withdrawal motivation: An updated review of the evidence","volume":"55","author":"Harmon\u2010Jones E","year":"2018","journal-title":"Psychophysiology"},{"key":"e_1_2_12_38_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.684926","article-title":"Effects of chronic pain treatment on altered functional and metabolic activities in the brain: A systematic review and meta\u2010analysis of functional neuroimaging studies","volume":"15","author":"Kim D","year":"2021","journal-title":"Front. Neurosci."},{"key":"e_1_2_12_39_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.816435","article-title":"Significant structural alterations and functional connectivity alterations of cerebellar gray matter in patients with somatic symptom disorder","volume":"16","author":"Liang H\u2010B","year":"2022","journal-title":"Front. Neurosci."},{"key":"e_1_2_12_40_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2025.111326","article-title":"Common neural correlates of chronic pain\u2013a systematic review and meta\u2010analysis of resting\u2010state fMRI studies","volume":"138","author":"Fi\u00faza\u2010Fernandes J","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_65_23","article-title":"Novel intervention of high\u2010frequency repetitive transcranial magnetic stimulation in patients with somatic symptom disorder and its safety and outcome","volume":"65","author":"Kumar N","year":"2023","journal-title":"Indian J. Psychiatry."}],"container-title":["Psychiatry and Clinical Neurosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.70127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pcn.70127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcn.70127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:27:19Z","timestamp":1788755239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcn.70127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":40,"alternative-id":["10.1111\/pcn.70127"],"URL":"https:\/\/doi.org\/10.1111\/pcn.70127","archive":["Portico"],"relation":{},"ISSN":["1323-1316","1440-1819"],"issn-type":[{"value":"1323-1316","type":"print"},{"value":"1440-1819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pcn.70127"}}