{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:07:43Z","timestamp":1790136463966,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Bipolar depression (BDD) and major depressive disorder (MDD) share similar depressive symptoms but differ in diagnosis, treatment, and prognosis. Clarifying their neurobiological distinctions may improve diagnostic characterization and mechanistic understanding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 453 participants, including 85 patients with BDD, 190 with MDD, and 178 healthy controls. Individual morphometric similarity networks (MSN) were constructed using seven structural and diffusion MRI features. Regional MSN differences between BDD and MDD were examined at the parcel level. To characterize the biological relevance of the distinct MSN pattern, we performed imaging\u2010transcriptomic analysis using Allen Human Brain Atlas data, followed by gene enrichment, cell\u2010type enrichment, receptor\/transporter dominance analysis, and cognitive meta\u2010analytic decoding. Sensitivity analyses evaluated the effects of medication exposure and demographic imbalance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with MDD, BDD showed distinct MSN alterations mainly in parietal and occipital regions, including higher MSN in the left lateral occipital cortex and lower MSN in the right inferior and superior parietal cortices. The spatial transcriptomic pattern was enriched for ribosomal and protein synthesis\/modification pathways. Cell\u2010type enrichment analyses showed that the transcriptomic pattern associated with the MSN differences was enriched for microglial and inhibitory\u2010neuron gene signatures, while receptor dominance analysis identified the 5\u2010HT\n                      <jats:sub>2A<\/jats:sub>\n                      density map as having the largest relative contribution to the explained spatial variance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings identify distinct cortical morphometric organization in BDD and MDD, and these differences are linked to transcriptomic, cellular, and neurotransmitter\u2010related annotations, providing multiscale insights into the neurobiological divergence between the two disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pcn.70137","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:46:56Z","timestamp":1790135216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct pattern in bipolar depression and major depressive disorder: A multiscale imaging\u2010transcriptomic analysis"],"prefix":"10.1111","author":[{"given":"Guangwei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine Southeast University  Nanjing China"},{"name":"Huai'an No. 3 People's Hospital Huaian Second Clinical College of Xuzhou Medical University  Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Massachusetts College of Pharmacy and Health Sciences University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Jiangsu Provincial Key Laboratory of Brain Science and Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha, Hunan 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