{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:53:11Z","timestamp":1791132791432,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Psychiatry Clin Neurosci"],"abstract":"<jats:p>\n                    Aperiodic electroencephalographic activity is proposed as a scalable marker of cortical population dynamics relevant to excitation\u2013inhibition balance. However, it remains unclear whether aperiodic parameters represent disorder\u2010specific abnormalities or context\u2010sensitive indices of clinically relevant brain states. Consistent with systematic\u2010review guidelines and a prospectively registered protocol, Ovid databases and PubMed were searched from inception through February 9, 2026, with updated manual searching conducted through July 14, 2026. Peer\u2010reviewed studies reporting electroencephalography\u2010derived aperiodic parameters in adults with schizophrenia\u2010spectrum disorders, major depressive disorder, treatment\u2010resistant depression, and\/or bipolar disorder were eligible. Studies lacking aperiodic outcomes or separable findings for eligible diagnoses were excluded. Two reviewers independently conducted study screening, data extraction, and risk\u2010of\u2010bias assessments. Findings were synthesized narratively by diagnosis, recording context, and parameter. Thirty articles (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20092298 aggregate participants) spanning cross\u2010sectional, longitudinal, and interventional designs were included. Findings in schizophrenia\u2010spectrum disorders were heterogeneous, with several studies reporting steeper slopes, higher offsets, or reduced temporal flexibility relative to healthy controls. Task\u2010related and dynamic measures often showed greater clinical relevance than static resting\u2010state parameters. Studies of major depressive disorder and treatment\u2010resistant depression more consistently reported flatter slopes and reduced offsets, particularly in central and posterior regions, with evidence from sleep and intracranial recordings. Aperiodic parameters were sensitive to treatment\u2010related modulation, although the direction of change differed across interventions. Bipolar disorder evidence was limited, and methodological heterogeneity precluded quantitative synthesis. Aperiodic electroencephalographic activity may be more informative as a context\u2010sensitive, within\u2010subject marker of cortical state and treatment\u2010related change than a fixed diagnostic signature. Methodological harmonization and direct physiological validation remain necessary before clinical implementation.\n                  <\/jats:p>","DOI":"10.1111\/pcn.70143","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:28:58Z","timestamp":1791131338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transdiagnostic patterns of electroencephalography (\n                    <scp>EEG<\/scp>\n                    )\u2010derived aperiodic activity across schizophrenia\u2010spectrum, bipolar, and depressive disorders: A systematic review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-0086","authenticated-orcid":false,"given":"Gia Han","family":"Le","sequence":"first","affiliation":[{"name":"Institute of Medical Science, Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Poul Hansen Family Centre for Depression, Krembil 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Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Schizophrenia Division Centre for Addiction and Mental Health (CAMH)  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian\u2010Daniel","family":"Llach","sequence":"additional","affiliation":[{"name":"Poul Hansen Family Centre for Depression, Krembil Brain Institute University Health Network  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Rosenblat","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Poul Hansen Family Centre for Depression, Krembil Brain Institute University Health Network  Toronto Ontario Canada"},{"name":"Department of Pharmacology and Toxicology University of Toronto  Toronto Ontario Canada"},{"name":"Department 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