{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:01:10Z","timestamp":1789506070725,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    En coup de sabre (\n                    <jats:styled-content style=\"fixed-case\">ECDS<\/jats:styled-content>\n                    ) and Parry\u2010Romberg syndrome (\n                    <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content>\n                    ) are variants of linear morphea on the head and neck that can be associated with neurologic manifestations. Intracranial abnormalities on computed tomography (\n                    <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                    ) and magnetic resonance imaging (\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    ) are present in a significant proportion of individuals with these conditions. We describe 32 children from our institution with\n                    <jats:styled-content style=\"fixed-case\">ECDS<\/jats:styled-content>\n                    or\n                    <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content>\n                    ; neuroimaging was performed in 21 cases. We also review 51 additional cases from the literature. Nineteen percent of the children at our institution with\n                    <jats:styled-content style=\"fixed-case\">ECDS<\/jats:styled-content>\n                    or\n                    <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content>\n                    had intracranial abnormalities on\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    , half of whom were asymptomatic. Hyperintensities on\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    2\u2010weighted sequences were the most common finding, present in all children with intracranial abnormalities on\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    . Seizures (13%) and headaches (9%) were the most common neurologic symptom. Neurologic symptoms were not correlated with neuroimaging abnormalities, with two asymptomatic children having marked\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    findings and only two of nine symptomatic children having an abnormal\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    . Similarly the severity of the superficial disease did not predict neurologic involvement; a child with subtle skin involvement had striking\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    findings and seizures, whereas another with a bony defect had no brain parenchymal involvement. Neurologic symptoms and neuroimaging abnormalities are found in a surprisingly substantial percentage of children with\n                    <jats:styled-content style=\"fixed-case\">ECDS<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content>\n                    . Early recognition of neurologic involvement is necessary because it affects treatment choices. Because clinical predictors of intracranial abnormalities are poor, strong consideration should be given to obtaining an\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    before treatment initiation to assist in management decisions and establish a baseline examination.\n                  <\/jats:p>","DOI":"10.1111\/pde.12001","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T12:51:01Z","timestamp":1351515061000},"page":"738-748","source":"Crossref","is-referenced-by-count":95,"title":["A Significant Proportion of Children with Morphea En Coup De Sabre and Parry\u2010Romberg Syndrome Have Neuroimaging Findings"],"prefix":"10.1111","volume":"29","author":[{"given":"Yvonne E.","family":"Chiu","sequence":"first","affiliation":[{"name":"Division of Pediatric Dermatology Department of Dermatology Medical College of Wisconsin Milwaukee 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