{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:28:37Z","timestamp":1780471717786,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Acute hemorrhagic edema of infancy (AHEI<\/jats:styled-content>) is an unusual form of leukocytoclastic vasculitis with dramatic distinguishing skin lesions that occurs in infants ages 4 to 24\u00a0months old. The disease presents with skin eruptions that usually start with large (1\u20135\u00a0cm), symmetrically distributed, hemorrhagic lesions in a characteristic cockade pattern. The lesions are typically located on the lower extremities, face (in particular the ears, cheeks, and eyelids), and gluteal area. Fever may accompany skin eruptions. Clinical presentation at onset requires clinical and laboratory examination to distinguish it from more serious diseases and other vasculitis. The main differential diagnosis of AHEI<\/jats:styled-content> is H<\/jats:styled-content>enoch\u2010S<\/jats:styled-content>ch\u00f6nlein purpura. AHEI<\/jats:styled-content> is generally a self\u2010limiting disease, so a conservative approach should be considered. Topical or systemic corticosteroid therapy has been reported to be beneficial, as well as antihistamines and dapsone, although AHEI<\/jats:styled-content> usually resolves completely with or without treatment. We report two cases of AHEI<\/jats:styled-content> and an update of the literature.<\/jats:p>","DOI":"10.1111\/pde.12004","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T16:31:59Z","timestamp":1353515519000},"source":"Crossref","is-referenced-by-count":31,"title":["Acute Hemorrhagic Edema of Infancy: A Troubling Cutaneous Presentation with a Self\u2010Limiting Course"],"prefix":"10.1111","volume":"30","author":[{"given":"Francesco","family":"Savino","sequence":"first","affiliation":[{"name":"Department of Pediatrics Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Lupica","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Tarasco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Viola","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca C.","family":"di Montezemolo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Coppo","sequence":"additional","affiliation":[{"name":"Dermatology Unit Department of Surgery Regina Margherita Children's Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1913.04350010020008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808323113"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03917.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.0024d.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0599-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80202-7"},{"key":"e_1_2_6_9_1","first-page":"127","article-title":"Infantile acute hemorrhagic edema of the skin","volume":"68","author":"Paradisi M","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb13904.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.122741"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:20:11Z","timestamp":1696033211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/pde.12004"],"URL":"https:\/\/doi.org\/10.1111\/pde.12004","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}