{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:41:51Z","timestamp":1791420111052,"version":"4.3.3"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infantile hemangiomas (<jats:styled-content style=\"fixed-case\">IHs<\/jats:styled-content>) are common benign tumors of childhood. <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s often regress satisfactorily without intervention, but a subset of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s may lead to functional or cosmetic morbidity necessitating therapy. <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome is characterized by a variety of neurocutaneous and vascular anomalies that typically include segmental hemangiomas. We present an infant with <jats:styled-content style=\"fixed-case\">PHACE<\/jats:styled-content> syndrome and segmental IH that failed conventional first\u2010line therapies. Treatment with sirolimus provided benefit with regression of the cutaneous <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>. As an inhibitor of the mammalian target of rapamycin (m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content>) pathway, the effective use of sirolimus may shed light on the emerging role of m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> signaling in the development and pathogenesis of <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/pde.12023","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T07:28:40Z","timestamp":1358234920000},"source":"Crossref","is-referenced-by-count":44,"title":["Treatment of Infantile Hemangiomas with Sirolimus in a Patient with <scp>PHACE<\/scp> Syndrome"],"prefix":"10.1111","volume":"30","author":[{"given":"Samer","family":"Kaylani","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J.","family":"Theos","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Pressey","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.00102.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890270083012"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1567"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20784"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2011.33"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31189"},{"key":"e_1_2_4_8_1","first-page":"CD006545","article-title":"Interventions for infantile haemangiomas (strawberry birthmarks) of the skin","author":"Leonardi\u2010Bee J","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903036"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006460"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09848.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32833bb764"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.630"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.300"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23124"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22766"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:19:16Z","timestamp":1696033156000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/pde.12023"],"URL":"https:\/\/doi.org\/10.1111\/pde.12023","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}