{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:23Z","timestamp":1787015963729,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T00:00:00Z","timestamp":1350345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 7\u2010year\u2010old boy developed severe toxic epidermal necrolysis (\n                    <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                    ) secondary to carbamazepine and was transferred to our center after further deterioration despite receiving one dose of intravenous immunoglobulin. After administration of one dose of infliximab, there was a clear halting of progression of blistering and an apparent dramatic improvement. We consider it likely that the administration of infliximab led to the improvement in this child and that anti\u2010tumor necrosis factor\u2010alpha therapy may be a logical treatment for\n                    <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                    , given the possible underlying pathologic process. Well\u2010conducted studies on the safety and efficacy of any such treatment are urgently required.\n                  <\/jats:p>","DOI":"10.1111\/pde.12029","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T23:52:37Z","timestamp":1350431557000},"page":"532-534","source":"Crossref","is-referenced-by-count":43,"title":["Toxic Epidermal Necrolysis in a Child Successfully Treated with Infliximab"],"prefix":"10.1111","volume":"31","author":[{"given":"Victoria","family":"Scott\u2010Lang","sequence":"first","affiliation":[{"name":"Department of Dermatology Royal Infirmary of Edinburgh Edinburgh Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tidman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Infirmary of Edinburgh Edinburgh Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McKay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Infirmary of Edinburgh Edinburgh Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/archderm.1994.01690050073012","article-title":"Macrophages and tumor necrosis factor \u03b1 in toxic epiderma necrolysis","volume":"130","author":"Paquet P","year":"1994","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.029"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.46833.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1080\/00015550510037062","article-title":"Toxic epidermal necrolysis associated with high intake of sildenafil and its response to infliximab","volume":"85","author":"Al\u2010Shouli S","year":"2005","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0462"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.00893.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00616.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K001"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12029","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T09:57:53Z","timestamp":1695463073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,16]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/pde.12029"],"URL":"https:\/\/doi.org\/10.1111\/pde.12029","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,16]]}}}