{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:30:07Z","timestamp":1791063007561,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T00:00:00Z","timestamp":1352678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granulomatosis with polyangiitis (<jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content>), also known as Wegener's granulomatosis, is a rare disease in childhood. Of 39 <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content> patients that we diagnosed during a 20\u2010year period, only 3 (7.7%) were younger than 18 years. We report the course of <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content> in three girls whose disease started at the ages of 16, 11, and 6\u00a0years. All had cutaneous manifestations: the first had necrotizing vasculitis, the second had palpable purpura, and the third had right upper\u2010eyelid edema and infiltration and proptosis caused by extraocular pseudotumor, initially histologically misdiagnosed as orbital immunoglobulin G4 (IgG4)\u2010related disease. Unlike with skin vasculitis and glomerulonephritis, upper\u2010airway and orbital inflammation were resistant to immunosuppressive therapy. Our report emphasizes that children presenting with cutaneous vasculitis, chronic eyelid swelling, sinusitis, or hoarseness should be tested for antineutrophil cytoplasmic antibodies. We emphasize that the upper\u2010eyelid edema and infiltration, with histologic characteristics of orbital IgG4\u2010related disease, may be the initial presentation of localized <jats:styled-content style=\"fixed-case\">GPA<\/jats:styled-content> in children, a feature that, until now, has been described only in adults.<\/jats:p>","DOI":"10.1111\/pde.12034","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T17:22:48Z","timestamp":1352740968000},"source":"Crossref","is-referenced-by-count":28,"title":["Granulomatosis with Polyangiitis (Wegener's Granulomatosis) in Children: Report of Three Cases with Cutaneous Manifestations and Literature Review"],"prefix":"10.1111","volume":"30","author":[{"given":"Mirjana","family":"Gajic\u2010Veljic","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Department of Dermatovenereology Clinical Center of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Department of Dermatovenereology Clinical Center of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Peco\u2010Antic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Department of Nephrology University Children's Hospital Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Institute of Mother and Child Healthcare of Serbia \u201cDr. Vukan Cupic\u201d Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sladjana","family":"Andrejevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Department of Allergy and Clinical Immunology Clinical Center of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Bonaci\u2010Nikolic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade Belgrade Serbia"},{"name":"Department of Allergy and Clinical Immunology Clinical Center of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"e_1_2_7_3_1","first-page":"S82","article-title":"Epidemiology of Wegener's granulomatosis: lessons from descriptive studies and analyses of genetic and 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