{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:55:40Z","timestamp":1774976140628,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Standard teaching dictates that systemic therapy is required for treatment of onychomycosis. It is unknown whether topical antifungal therapy is effective for pediatric nail infections. This prospective, randomized, double\u2010blind, vehicle\u2010controlled study was conducted in the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ediatric <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nit at <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ady <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildren's <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital to determine whether topical antifungal therapy is efficacious for pediatric onychomycosis. Forty patients ages 2 to 16\u00a0years with nonmatrix onychomycosis were randomized 1:3 to ciclopirox lacquer or vehicle lacquer. Ciclopirox lacquer or vehicle was applied daily for 32\u00a0weeks, with weekly removal of the lacquer and mechanical trimming. Those with poor response were crossed over to active drug at week 12. Thirty\u2010seven patients completed the 32\u2010week study, and follow\u2010up data were collected 1\u00a0year after completion of the study from 24 patients. Mycologic cure, effective treatment, and complete cure were assessed, as well as adverse events and effect on quality of life. Mycologic cure was 70% in the treated group and 20% in the vehicle arm (p\u00a0=\u00a00.03) at week 12. At end of the study (week 32), 77% of treated patients achieved mycologic cure and 71% effective treatment, compared with 22% of the control group. Ninety\u2010two percent of those who were cured and followed for 1\u00a0year remained clear. Topical antifungal lacquer (ciclopirox) can be an effective option for children with nonmatrix onychomycosis. Pediatric onychomycosis does not always require systemic therapy and responds better to topical therapy than does adult disease.<\/jats:p>","DOI":"10.1111\/pde.12064","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T10:14:11Z","timestamp":1356689651000},"page":"316-322","source":"Crossref","is-referenced-by-count":48,"title":["Onychomycosis Does Not Always Require Systemic Treatment for Cure: A Trial Using Topical Therapy"],"prefix":"10.1111","volume":"30","author":[{"given":"Shiela Fallon","family":"Friedlander","sequence":"first","affiliation":[{"name":"Division of Pediatric and Adolescent Dermatology Rady Children's Hospital\u2013San Diego and University of California at San Diego School of Medicine San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuin C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Dermatology Associates Gleneagles Medical Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiong H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Yong Loo Lin School of Medicine National University Health System Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence F.","family":"Eichenfield","sequence":"additional","affiliation":[{"name":"Division of Pediatric and Adolescent Dermatology Rady Children's Hospital\u2013San Diego and University of California at San Diego School of Medicine San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.109071"},{"key":"e_1_2_13_3_1","first-page":"383","article-title":"Two hundred ninety\u2010six cases of onychomycosis in 455 children and teenagers: a 10\u2010year laboratory survey","volume":"456","author":"Lateur N","year":"2003","journal-title":"Pediatr Dermatol"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/10.4.401"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01161.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01802.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80215-0"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80142-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01284.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01186.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70321-9"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01761.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpde.12064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.12064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:59:14Z","timestamp":1698703154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.12064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,28]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/pde.12064"],"URL":"https:\/\/doi.org\/10.1111\/pde.12064","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,28]]}}}